Simulations of a Multipinhole SPECT Collimator for Clinical Dopamine Transporter (DAT) Imaging
Simulations of a Multipinhole SPECT Collimator for Clinical Dopamine Transporter (DAT) Imaging
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DOI：
10.1109/trpms.2018.2831208
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发表时间：
2018-09-01
影响因子：
4.4
通讯作者：
King, Michael A.
中科院分区：
文献类型：
--
作者：
Konik, Arda;De Beenhouwer, Jan;King, Michael A.
多巴胺转运蛋白（DAT）的SPECT成像用于诊断和监测帕金森病（PD）的进展，以及将PD与其他神经系统疾病区分开来。诊断是基于纹状体中尾状核和壳核结构中的DAT结合。我们以前提出了一个相对便宜的方法，以改善双头SPECT的这些结构的检测和定量，通过更换一个专门设计的多针孔（MPH）准直器的扇束准直器。在本文中，我们开发了一个现实的模型，建议MPH系统使用GATE模拟包和验证的几何形状与分析模拟器。来自这些模拟的点源投影紧密匹配，确认针孔几何形状的准确性。热棒体模的重建表明，4.8 mm的分辨率是可以实现的。XCAT脑体模的重建显示壳核和尾状核的清晰分离，这有望改善DAT成像和PD诊断的定量。使用该GATE模型，将生成模拟物理因素的点扩散函数以用于重建。此外，正在研究几何形状的进一步改进，以提高该基础系统的灵敏度，同时保持4.5-5 mm的目标空间分辨率。
SPECT imaging of the dopamine transporter (DAT) is used for diagnosis and monitoring progression of Parkinson's disease (PD), and differentiation of PD from other neurological disorders. The diagnosis is based on the DAT binding in the caudate and putamen structures in the striatum. We previously proposed a relatively inexpensive method to improve the detection and quantification of these structures for dual-head SPECT by replacing one of the fan-beam collimators with a specially designed multipinhole (MPH) collimator. In this paper, we developed a realistic model of the proposed MPH system using the GATE simulation package and verified the geometry with an analytic simulator. Point source projections from these simulations closely matched confirming the accuracy of the pinhole geometries. The reconstruction of a hot-rod phantom showed that 4.8-mm resolution is achievable. The reconstructions of the XCAT brain phantom showed clear separation of the putamen and caudate, which is expected to improve the quantification of DAT imaging and PD diagnosis. Using this GATE model, point spread functions modeling physical factors will be generated for use in reconstruction. Also, further improvements in geometry are being investigated to increase the sensitivity of this base system while maintaining a target spatial resolution of 4.5-5 mm.