Rat somatosensory (SmI) cortex: II. Laminar and columnar organization of noxious and non-noxious inputs
Rat somatosensory (SmI) cortex: II. Laminar and columnar organization of noxious and non-noxious inputs
复制标题
大鼠体感（SmI）皮层：II。
作者：
Y. Lamour;G. Guilbaud;J. Willer
摘要采用电极轨迹的组织学重建方法，研究了在卤素二氮麻醉下，垂直于皮层表面的微电极穿透时大鼠SmI皮层的层状和柱状组织。神经元的感受野特性（见相关论文）和层流分布进行了研究。非有害皮肤刺激驱动的神经元和非有害深层刺激驱动的神经元，在对侧感受野的相同穿透中可以被记录下来。仅在48%的病例中观察到形态特异性穿透。这一发现表明，在大鼠SmI皮层中几乎没有亚模态分离。在一个给定的穿透中连续观察到的感受野通常是重叠的。在径向穿透过程中，“形态特异性”柱比“地点特异性”柱更少被观察到。在同一刺入过程中，非有害刺激驱动的神经元和有害刺激驱动的神经元可以依次被记录下来。非有害皮肤刺激驱动的神经元主要分布在第2层至第5层，在第6层少见。相反，伤害性特异性神经元几乎全部分布在第2层和第6层，而收敛性神经元分布在第5层。感受野的大小是神经元层状位置的函数：平均而言，第IV层感受野较小，第II-III和第V层感受野较大，第VI层感受野更大。受有害刺激驱动的神经元感受野的体位组织与非有害刺激驱动的神经元不同。这种差异部分是由于受有害刺激驱动的神经元的接受区更大，以及它们不同的地形组织。这些结果为大鼠SmI皮层的功能提供了新的数据。也就是说，他们表明，皮层对身体无害和有害输入的处理是基于层流和柱状的组织模式。
SummaryThe laminar and columnar organization of the rat SmI cortex was investigated under halothanenitrous oxide anaesthesia during microelectrode penetrations perpendicular to the cortical surface, using histological reconstruction of the electrode tracks. Neurons were studied in terms of receptive field properties (see companion paper) and laminar distribution. Neurons driven by non-noxious cutaneous stimulation and others by non-noxious deep stimulation, applied on contralateral receptive fields, could be recorded in the same penetration. Modality specific penetrations were observed in 48% of cases only. This finding suggests that there is little submodality segregation in the rat SmI cortex. Receptive fields successively observed in a given penetration were usually overlapping. “Modality-specific” columns were less often observed than “place-specific” columns during radial penetrations. Neurons driven by non-noxious stimulation as well as neurons driven by noxious stimulation could be recorded successively in the same penetration. Neurons driven by non-noxious cutaneous stimulation were found in layers II to V and were rare in layer VI. In contrast, nociceptive specific neurons were found almost exclusively in layers Vb and VI and convergent neurons in layer V. The size of the receptive fields was a function of the laminar position of the neurons: receptive fields were, on the average, small in layer IV, larger in layer II–III and V and even larger in layer VI. The somatotopic organization of the receptive fields of neurons driven by noxious stimulation was different from that of neurons driven by non-noxious stimulation. Such a difference was due in part to the larger size of the receptive fields of the neurons driven by noxious stimulation and also to their different topographical organization. These results provide new data concerning the functions of the rat SmI cortex. Namely they show that the cortical processing of somatic non-noxious and noxious inputs is based on laminar as well as columnar patterns of organization.
影响因子：
2.5
作者：
KENSHALO, DR;GIESLER, GJ;WILLIS, WD
通讯作者：
WILLIS, WD