Histamine content and histamine H1 receptor in experimentally-induced nasal hypersensitivity.
Histamine content and histamine H1 receptor in experimentally-induced nasal hypersensitivity.
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实验诱导的鼻超敏反应中的组胺含量和组胺 H1 受体。
DOI：
10.3109/00016488909138629
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
T. Kumazawa
中科院分区：
文献类型：
--
作者：
N. Kubo;Y. Hori;K. Tomoda;T. Yamashita;T. Kumazawa
在预先确定的致敏期，在特定时间点对甲苯二异氰酸酯致敏豚鼠鼻黏膜进行组胺和组胺H1受体的定量评价。组胺含量在1周显著增加，在2周后明显升高。这种增加在整个致敏期保持不变。致敏后4周降至正常。同时，TDI刺激后组胺含量较低，说明TDI刺激释放了一定量的组胺。另一方面，组胺H1受体的密度和亲和力在TDI致敏过程中没有发现改变。这些结果表明，增强的组胺在鼻过敏的发展中起作用，而在鼻过敏中观察到的H1受体的数量改变与组胺超敏反应的相关性尚未得到证实。
Quantitative evaluations of histamine and histamine H1 receptor were carried out in nasal mucosa of toluene diisocyanate (TDI) sensitized guinea-pigs at specific points in time during a pre-determined sensitization period. Histamine content is significantly increased at 1 week and definitely elevated after 2 weeks of sensitization. This increase was maintained throughout the sensitization period. It decreased to normal by four weeks post-sensitization. Also the relatively low histamine content immediately after TDI challenge indicated that a certain amount of histamine was released by TDI challenge. On the other hand, the density and affinity of the histamine H1 receptor was not found to be altered during TDI sensitization. These results suggest that enhanced histamine has a role in the development of nasal allergy, whereas the relevance of quantitative-alteration of the H1 receptor to histamine hypersensitivity observed in nasal allergy has not been demonstrated.