Functional interplay between stimulus-oriented and stimulus-independent attending during a prospective memory task
Functional interplay between stimulus-oriented and stimulus-independent attending during a prospective memory task
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DOI：
10.1016/j.neuropsychologia.2013.12.001
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发表时间：
2014-01-01
期刊：
影响因子：
2.6
通讯作者：
Costa, Alberto
中科院分区：
文献类型：
--
作者：
Barban, Francesco;Carlesimo, Giovanni Augusto;Costa, Alberto
最近的研究表明，布罗德曼10区的内侧（medBA 10）和外侧（latBA 10）部分分别有助于前瞻记忆（PM）任务中的刺激导向（SO）和刺激独立（SI）注意。我们研究了这种分离通过操纵显着性（SO）和记忆负荷（SI）的PM线索。16名健康受试者参加了一项2 x 2 x 2实验设计的功能成像方案，包括以下因素：任务（持续目标与PM线索），显著性（高与低;目标/线索嵌入或突出于干扰物）和记忆负荷（高与低; 1或4个可能的PM目标）。我们通过定位器任务定位了medBA 10和latBA 10。在medBA 10中，我们发现了一个显着的高显着性和低记忆负荷的主效应;而在左latBA 10中，我们发现了一个显着的任务x负荷的相互作用，与最大激活PM线索在高负荷条件下。这些结果是在协议的网关假设：在PM任务medBA 10偏向注意对外部显着刺激，SO出席，而latBA 10偏向注意内部记忆表征，SI出席。额外的全脑分析强调了除了BA 10之外的其他区域的激活，这与最近强调PM性能期间分布式网络的作用的建议一致。(C)2013爱思唯尔有限公司保留所有权利。
Recent studies have suggested that medial (medBA10) and lateral (latBA10) portions of the Brodmann area 10 subserve respectively stimulus-oriented (SO) and stimulus-independent (SI) attending during prospective memory (PM) tasks. We investigated this dissociation by manipulating the saliency (SO) and the memory load (SI) of PM cues. Sixteen healthy subjects participated to a functional imaging protocol with a 2 x 2 x 2 experimental design, including the factors: task (ongoing target vs. PM cue), Saliency (high vs. low; with targets/cues either embedded or standing out from distracters), and memory load (high vs. low; with 1 or 4 possible PM targets). We localized the medBA10 and latBA10 by means of a localizer task. In medBA10 we found a significant main effects of high Saliency and low memory load; whereas in the left latBA10, we found a significant task x load interaction, with maximal activation for PM cues presented in the high load condition. These results are in agreement with the gateway hypothesis: during a PM task medBA10 biases attention toward external salient stimuli, SO attending, while latBA10 biases attention toward internal mnemonic representations, SI attending. Additional whole-brain analyses highlighted activation of other areas besides BA10, consistent with recent proposals that emphasise the role of distributed networks during PM performance. (C) 2013 Elsevier Ltd. All rights reserved.