Skull base atypical meningioma: Long term surgical outcome and prognostic factors
Skull base atypical meningioma: Long term surgical outcome and prognostic factors
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DOI：
10.1016/j.clineuro.2014.11.009
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发表时间：
2015-01-01
影响因子：
1.9
通讯作者：
Chen, Pin-Yuan
中科院分区：
文献类型：
--
作者：
Wang, Yu-Chi;Chuang, Chi-Cheng;Chen, Pin-Yuan
目的：本研究的目的是检查手术切除和辅助放疗后治疗颅底区非典型脑膜瘤的临床结果，并分析临床特征和无进展survival.Materials和方法之间的关联：28例颅底非典型脑膜瘤进行显微手术切除2001年6月至2009年11月。结果：随访期间，13例（46.4%）脑膜瘤复发或进展。中位疾病进展时间为64个月。手术切除的范围显著影响预后。与次全切除相比，肿瘤的大体全切除（GTR）改善了无进展生存期（PFS）（STR，p = 0.011）。诊断时年龄较大的患者也会导致更差的结局（p = 0.024）。MIB-1索引
Purpose: The aim of this study was to examine the clinical outcomes of treating atypical meningioma at the skull base region following surgical resection and adjuvant radiotherapy, and to analyze the association between clinical characteristics and progression free survival.Materials and methods: Twenty-eight patients with skull base atypical meningiomas underwent microsurgical resection between June 2001 and November 2009. The clinical characteristics of the patients and meningiomas, the extent of surgical resection, and complications after treatment were retrospectively analyzed.Results: Thirteen patients (46.4%) had disease recurrence or progression during follow up time. The median time to disease progression was 64 months. The extent of the surgical resection significantly impacted prognosis. Gross total resection (GTR) of the tumor improved progression free survival (PFS) compared to subtotal resection (STR, p = 0.011). An older patient age at diagnosis also resulted in a worse outcome (p = 0.024). An MIB-1 index