Immunologic mechanisms in hypersensitivity reactions to metal ions: an overview
Immunologic mechanisms in hypersensitivity reactions to metal ions: an overview
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金属离子过敏反应的免疫机制：概述
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
L. Büdinger
中科院分区：
文献类型：
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作者：
L. Büdinger;M. Hertl;L. Büdinger
金属离子如Ni2+、Co2+、Cu2+或Cr3+是具有很高免疫原性的半抗原，因为离子金属引起的接触性皮炎发生在大约10%-15%的人群中。由于含有Ni2+、Co2+和Cr3+的合金是替代手术、义齿、正畸金属丝和各种其他设备中的植入物的组成部分，金属离子的不良反应在实际医学中造成了严重的问题，如与含金属的生物材料的不相容反应。另一方面，金属离子如Ni2+的接触性皮炎是研究免疫系统识别半抗原所涉及的分子机制的一个成熟的模型。虽然已经进行了许多研究来阐明导致人类接触性超敏的分子相互作用，但仍有许多方面需要澄清。这篇综述将集中于迄今为止积累的关于T细胞识别金属离子和引起不良免疫反应导致接触性皮炎的免疫学机制的实验数据。
Metal ions such as Ni2+, Co2+, Cu2+, or Cr3+ are haptens with a high immunogenic potential, as contact dermatitis caused by ionic metals occurs in about 10–15% of the human population. Since alloys containing Ni2+, Co2+, and Cr3+ are components of implants in replacement surgery, dentures, orthodontic wires, and various other devices, adverse reactions to metal ions create serious problems in practical medicine as incompatibility reactions to metal‐containing biomaterials. On the other hand, contact dermatitis to metal ions such as Ni2+ is a well‐established model for studying the molecular mechanisms involved in the recognition of haptens by the immune system. Although many investigations have been performed to elucidate the molecular interactions causing contact hypersensitivity in man, many aspects remain to be clarified. This review will focus on the experimental data accumulated so far on the immunologic mechanisms responsible for the recognition of metal ions by T cells and eliciting adverse immune reactions causing contact dermatitis.
特应性皮炎中 IL-10 的过度表达。
DOI：
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发表时间：
1995
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Ohmen,JD;Hanifin,JM;Nickoloff,BJ;Rea,TH;Wyzykowski,R;Kim,J;Jullien,D;McHugh,T;Nassif,AS;Chan,SC
通讯作者：
Chan,SC