Prognostic Factors in Stage III Non-Small-Cell Lung Cancer Patients

Prognostic Factors in Stage III Non-Small-Cell Lung Cancer Patients
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III 期非小细胞肺癌患者的预后因素

DOI:
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发表时间:
2016
影响因子:
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通讯作者:
N. Turan
N. Turan
中科院分区:
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文献类型:
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作者:
S. Urvay;B. Yucel;E. Erdiş;N. Turan

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目的:本研究的目的是探讨影响III期非小细胞肺癌(NSCL)患者同时或序贯放化疗(CRT)生存率的预后因素。方法和材料:我们回顾性分析了2007年至2015年期间接受治疗的148例晚期、不可手术的III期NSCLC患者的临床记录。结果:中位生存期为19个月,3年总生存率为27%。在单因素分析中,年龄(<65岁vs ≥65岁,p=0.026)、分期(IIIA vs IIIB,p=0.033)、放疗(RT)剂量(<60 vs ≥60戈伊,p=0.024)和治疗方法(序贯化疗+RT vs同期CRT,p=0.023)是影响生存率的因素。性别、组织学亚型、CRT期间体重减轻、体能状态、诱导/巩固化疗和合并症的存在对生存率没有影响(p>0.050)。结论:年轻、IIIA期、放疗剂量和同步放化疗对III期NSCLC患者的生存率有积极影响。
Aim: The objective of this study is to investigate prognostic factors affecting survival of patients undergoing concurrent or sequential chemoradiotherapy (CRT) for stage III non-small-cell lung cancer (NSCL). Methods and materials: We retrospectively reviewed the clinical records of 148 patients with advanced, inoperable stage III NSCLC, who were treated between 2007 and 2015. Results: The median survival was found to be 19 months and 3-year overall survival was 27%. Age (<65 vs ≥65 years, p=0.026), stage (IIIA vs IIIB, p=0.033), dose of radiotherapy (RT) (<60 vs ≥60 Gy, p=0.024) and treatment method (sequential chemotherapy+RT vs concurrent CRT, p=0.023) were found to be factors affecting survival in univariate analyses. Gender, histological subtype, weight loss during CRT, performance status, induction/consolidation chemotherapy and presence of comorbidities did not affect survival (p>0.050). Conclusion: Young age, stage IIIA, radiotherapy dose and concurrent chemoradiotherapy may positively affect survival in stage III NSCL cases.
DOI: 10.1200/jco.2006.07.3569
发表时间: 2007-05-01
影响因子: 45.3
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