Full-field transmission x-ray microscopy for bio-imaging.
Full-field transmission x-ray microscopy for bio-imaging.
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DOI：
10.1088/1742-6596/186/1/012081
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Yun W
中科院分区：
文献类型：
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作者：
Andrews JC;Brennan S;Liu Y;Pianetta P;Almeida EA;van der Meulen MC;Wu Z;Mester Z;Ouerdane L;Gelb J;Feser M;Rudati J;Tkachuk A;Yun W
SSRL的全视场硬X射线显微镜已成功地以40 nm分辨率对生物和环境来源的样品进行成像。为了研究负重对骨结构的影响，对一只雌性小鼠胫骨骨小梁进行了相位对比成像，显示了骨细胞和小管的复杂网络。暴露于汞的草根成像显示纳米颗粒具有强烈的吸收对比度。在富硒培养基中生长的酵母细胞的3D断层扫描显示了内部结构。
A full-field hard-x-ray microscope at SSRL has successfully imaged samples of biological and environmental origin at 40 nm resolution. Phase contrast imaging of trabeculae from a female mouse tibia, loaded in vivo to study the effects of weight-bearing on bone structure, revealed a complex network of osteocytes and canaliculi. Imaging of cordgrass roots exposed to mercury revealed nanoparticles with strong absorption contrast. 3D tomography of yeast cells grown in selenium rich media showed internal structure.