Meclofenamate sodium monohydrate inhibits chemotactic factor-induced human polymorphonuclear leukocyte function. A possible explanation for its antiinflammatory effect.
Meclofenamate sodium monohydrate inhibits chemotactic factor-induced human polymorphonuclear leukocyte function. A possible explanation for its antiinflammatory effect.
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甲氯芬那酸钠一水合物抑制趋化因子诱导的人多形核白细胞功能。
DOI：
10.1002/art.1780300909
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发表时间：
1987
影响因子：
--
通讯作者：
Marder,S
中科院分区：
文献类型：
--
作者：
Perez,HD;Elfman,F;Marder,S
甲氯芬那酸钠一水合物 (MSM) 是一种有效的非甾体抗炎药，特异性抑制趋化因子诱导的人多形核白细胞功能：趋化性、脱颗粒和超氧阴离子自由基的产生。人们发现 MSM 的这些作用取决于未与白蛋白结合的药物（游离药物）的浓度，并且是由其在受体和受体后（即，多形核白细胞胞内 Ca2+ 动员的远端）水平上的干扰能力引起的。 MSM 的这些独特作用可能为其强大的抗炎作用提供了部分解释。
Meclofenamate sodium monohydrate (MSM), a potent nonsteroidal antiinflammatory agent, specifically inhibits chemotactic factor‐induced human polymorphonuclear leukocyte functions: chemotaxis, degranulation, and generation of superoxide anion radicals. These effects of MSM were found to be dependent upon the concentrations of drug not bound to albumin (free drug), and were caused by its ability to interfere at both a receptor and post‐receptor (i.e., a step distal to mobilization of polymorphonuclear leukocyte intracellular Ca2+) level. These unique actions of MSM may provide a partial explanation for its potent antiinflammatory effect.