Neurotrophic factors in spinal cord injury.
Neurotrophic factors in spinal cord injury.
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DOI：
10.1007/978-3-642-45106-5_16
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发表时间：
2014-01-01
影响因子：
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通讯作者：
Mendell, Lorne M
中科院分区：
文献类型：
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作者：
Boyce, Vanessa S;Mendell, Lorne M
修复受损脊髓的一个主要挑战是确保受损细胞的存活并促进切断的轴突再生。由于已知神经营养因子在发育期间影响这些过程，因此许多改善受损脊髓功能的实验方法都利用了这些试剂，特别是脑源性神经营养因子（BDNF）和神经营养因子-3（NT-3）。最近，神经营养因子也被证明会影响脊髓中细胞和突触的生理学。神经营养因子对回路性能的影响为其作为修复受损脊髓的试剂的考虑增加了一个重要方面。在本章中，我们将从结构和功能的角度讨论神经营养因子在促进脊髓损伤后恢复中的作用。
A major challenge in repairing the injured spinal cord is to assure survival of damaged cells and to encourage regrowth of severed axons. Because neurotrophins are known to affect these processes during development, many experimental approaches to improving function of the injured spinal cord have made use of these agents, particularly Brain derived neurotrophic factor (BDNF) and Neurotrophin-3 (NT-3). More recently, neurotrophins have also been shown to affect the physiology of cells and synapses in the spinal cord. The effect of neurotrophins on circuit performance adds an important dimension to their consideration as agents for repairing the injured spinal cord. In this chapter we discuss the role of neurotrophins in promoting recovery after spinal cord injury from both a structural and functional perspective.