Brain imaging in pediatric obsessive-compulsive disorder.
Brain imaging in pediatric obsessive-compulsive disorder.
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DOI：
10.1097/chi.0b013e318185d2be
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发表时间：
2008-11
影响因子：
13.3
通讯作者：
Rosenberg DR
中科院分区：
文献类型：
--
作者：
MacMaster FP;O'Neill J;Rosenberg DR
回顾了解儿科强迫症 (OCD) 的进展。重点是强迫症的额叶-纹状体-丘脑模型、该疾病的神经生物学和遗传学研究及其对最新治疗进展的影响。使用关键词“强迫症”以及“儿科”、“遗传学”和“影像学”进行计算机化文献检索。神经影像学研究发现了支持额叶-纹状体-丘脑模型的证据。遗传和神经化学研究也表明谷氨酸与强迫症的病理学有关。这导致了谷氨酸调节剂用于治疗强迫症的应用。对儿科强迫症的研究已经导致了一种精细的研究尽管取得了这些进展，但仍需要完全解释性的模型，以实现准确的预后并开发有针对性的有效治疗方法。
To review progress in understanding pediatric obsessive-compulsive disorder (OCD). The focus is on the frontal-striatal-thalamic model of OCD, neurobiological and genetic studies of the disorder and their influence on recent advances in treatment. Computerized literature searches were conducted with the keywords “obsessive-compulsive disorder” in conjunction with ‘pediatric”, “genetics” and “imaging”. Neuroimaging studies find evidence to support the frontal-striatal-thalamic model. Genetic and neurochemical studies also implicate glutamate in the pathology of OCD. This has led to application of glutamate modulating agents to treat OCD. Studies of pediatric OCD have led to a refined frontal-striatal-thalamic model of pathogenesis and are having an evidence-based impact on treatment. Despite this progress, fully explanatory models are still needed that would allow for accurate prognosis and the development of targeted and efficacious treatments.