Hyperbaric exposure with high oxygen concentration improves altered fiber types in the plantaris muscle of diabetic Goto-Kakizaki rats
Hyperbaric exposure with high oxygen concentration improves altered fiber types in the plantaris muscle of diabetic Goto-Kakizaki rats
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DOI：
10.2170/physiolsci.sc000707
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发表时间：
2007-04-01
影响因子：
2.3
通讯作者：
Ishihara, A.
中科院分区：
文献类型：
--
作者：
Matsumoto, A.;Nagatomo, F.;Ishihara, A.
高氧浓度高压暴露抑制糖尿病大鼠生长相关的葡萄糖和胰岛素增加。在这项研究中，将5周龄的糖尿病大鼠Goto-Kakizaki暴露在高氧浓度（36%）的高压环境（1.25大气压）中，每天6小时。研究了高压暴露4周后后藤- kakizaki大鼠快抽动跖肌纤维类型分布和氧化酶活性。高氧化I型和IIA型纤维的百分比增加，低氧化IIB型纤维的百分比减少。此外，无论纤维类型如何，纤维氧化酶活性在高压暴露后都有所增加。由此可见，糖尿病大鼠跖肌纤维类型的改变模式与非糖尿病大鼠一样，在高氧高压环境下向正常方向转变。
Hyperbaric exposure with high oxygen concentration inhibits a growth-related increase in the glucose and insulin of diabetic rats. In this study, 5-week-old diabetic Goto-Kakizaki rats were exposed to a hyperbaric environment (1.25 atmospheric pressure) with a high oxygen concentration (36%) for 6 h daily. Fiber type distributions and oxidative enzyme activities in the fast-twitch plantaris muscle of Goto-Kakizaki rats were examined after hyperbaric exposure for 4 weeks. The percentages of high-oxidative type I and type IIA fibers increased and that of low-oxidative type IIB fibers decreased after hyperbaric exposure. Furthermore, the fiber oxidative enzyme activity increased after hyperbaric exposure, regardless of fiber type. It is concluded that altered patterns of fiber types in the plantaris muscle of diabetic rats shift toward normal, which is observed in nondiabetic rats, following hyperbaric exposure with high oxygen concentration.