Effect of Polymer Concentration on Autoclaved Cryogel Properties
Effect of Polymer Concentration on Autoclaved Cryogel Properties
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DOI：
10.1002/mame.201900824
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发表时间：
2020-03-20
影响因子：
3.9
通讯作者：
Bencherif, Sidi A.
中科院分区：
文献类型：
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作者：
Memic, Adnan;Rezaeeyazdi, Mahboobeh;Bencherif, Sidi A.
生物材料灭菌是患者使用前的先决条件，特别是支架植入或注射时。美国食品和药物管理局强制执行各种灭菌工艺，包括高压蒸汽灭菌。尽管高压蒸汽或高压灭菌器灭菌可以消除病原体，但它通常会对水凝胶等软材料造成不可逆转的损害。在当前的研究中，分析了高压灭菌对由几种天然聚合前体（海藻酸盐、透明质酸和明胶）制成的冷冻凝胶的影响。具体来说，研究了聚合物浓度对高压灭菌冷冻凝胶的结构和物理性质（例如力学、溶胀比、孔互连性和形状记忆特征）的影响。结果表明，在给定的最佳聚合物浓度下（对于所研究的每种生物聚合物而言都是独一无二的），高压灭菌不会显着改变冷冻凝胶的微结构或物理特性，包括其注射器可注射性特征。总之，当在优化的聚合物浓度下配制时，可高压灭菌的冷冻凝胶在多种生物医学应用中具有巨大的潜力，因为它们可以很容易地转化为临床实践，以造福公众健康。
Biomaterial sterilization is a prerequisite prior to patient's use, especially for scaffold implantation or injection. Various sterilization processes are mandated by the Food and Drug Administration including high-pressure steam sterilization. Although high-pressure steam or autoclave sterilization eliminates pathogens, it often leads to irreversible damages on soft materials such as hydrogels. In the current study, the impact of autoclave sterilization on cryogels made from several naturally-derived polymeric precursors (alginate, hyaluronic acid, and gelatin) is analyzed. Specifically, the impact of polymer concentration on the structural and physical properties of autoclaved cryogels such as mechanics, swelling ratio, pore interconnectivity, and shape-memory features is studied. The results demonstrate that at a given optimal polymer concentration, unique for each biopolymer investigated, autoclave sterilization does not substantially alter the microarchitectural or physical characteristics of cryogels, including their syringe injectability signature. In summary, when formulated under optimized polymer concentrations, autoclavable cryogels hold great potential for several biomedical applications, as they can be easily translated into clinical practice to benefit public health.