Clonal haematopoiesis and risk of chronic liver disease.
Clonal haematopoiesis and risk of chronic liver disease.
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DOI：
10.1038/s41586-023-05857-4
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发表时间：
2023-04
期刊：
影响因子：
64.8
通讯作者：
Zoellner, Sebastian
中科院分区：
文献类型：
--
作者：
Wong, Waihay J.;Emdin, Connor;Bick, Alexander G.;Zekavat, Seyedeh M.;Niroula, Abhishek;Pirruccello, James P.;Dichtel, Laura;Griffin, Gabriel;Uddin, Md Mesbah;Gibson, Christopher J.;Kovalcik, Veronica;Lin, Amy E.;McConkey, Marie E.;Vromman, Amelie;Sellar, Rob S.;Kim, Peter G.;Agrawal, Mridul;Weinstock, Joshua;Long, Michelle T.;Yu, Bing;Banerjee, Rajarshi;Nicholls, Rowan C.;Dennis, Andrea;Kelly, Matt;Loh, Po-Ru;McCarroll, Steve;Boerwinkle, Eric;Vasan, Ramachandran S.;Jaiswal, Siddhartha;Johnson, Andrew D.;Chung, Raymond T.;Corey, Kathleen;Levy, Daniel;Ballantyne, Christie;Ebert, Benjamin L.;Natarajan, Pradeep;Abe, Namiko;Abecasis, Goncalo;Aguet, Francois;Albert, Christine;Almasy, Laura;Alonso, Alvaro;Ament, Seth;Anderson, Peter;Anugu, Pramod;Applebaum-Bowden, Deborah;Ardlie, Kristin;Arking, Dan;Arnett, Donna K.;Ashley-Koch, Allison;Aslibekyan, Stella;Assimes, Tim;Auer, Paul;Avramopoulos, Dimitrios;Ayas, Najib;Balasubramanian, Adithya;Barnard, John;Barnes, Kathleen;Barr, R. Graham;Barron-Casella, Emily;Barwick, Lucas;Beaty, Terri;Beck, Gerald;Becker, Diane;Becker, Lewis;Beer, Rebecca;Beitelshees, Amber;Benjamin, Emelia;Benos, Takis;Bezerra, Marcos;Bielak, Larry;Bis, Joshua;Blackwell, Thomas;Blangero, John;Blue, Nathan;Bowden, Donald W.;Bowler, Russell;Brody, Jennifer;Broeckel, Ulrich;Broome, Jai;Brown, Deborah;Bunting, Karen;Burchard, Esteban;Bustamante, Carlos;Buth, Erin;Cade, Brian;Cardwell, Jonathan;Carey, Vincent;Carrier, Julie;Carson, April P.;Carty, Cara;Casaburi, Richard;Casas Romero, Juan P.;Casella, James;Castaldi, Peter;Chaffin, Mark;Chang, Christy;Chang, Yi-Cheng;Chasman, Daniel;Chavan, Sameer;Chen, Bo-Juen;Chen, Wei-Min;Chen, Yii-Der Ida;Cho, Michael;Choi, Seung Hoan;Chuang, Lee-Ming;Chung, Mina;Chung, Ren-Hua;Clish, Clary;Comhair, Suzy;Conomos, Matthew;Cornell, Elaine;Correa, Adolfo;Crandall, Carolyn;Crapo, James;Cupples, L. Adrienne;Curran, Joanne;Curtis, Jeffrey;Custer, Brian;Damcott, Coleen;Darbar, Dawood;David, Sean;Davis, Colleen;Daya, Michelle;de Andrade, Mariza;de las Fuentes, Lisa;de Vries, Paul;DeBaun, Michael;Deka, Ranjan;DeMeo, Dawn;Devine, Scott;Dinh, Huyen;Doddapaneni, Harsha;Duan, Qing;Dugan-Perez, Shannon;Duggirala, Ravi;Durda, Jon Peter;Dutcher, Susan K.;Eaton, Charles;Ekunwe, Lynette;El Boueiz, Adel;Ellinor, Patrick;Emery, Leslie;Erzurum, Serpil;Farber, Charles;Farek, Jesse;Fingerlin, Tasha;Flickinger, Matthew;Fornage, Myriam;Franceschini, Nora;Frazar, Chris;Fu, Mao;Fullerton, Stephanie M.;Fulton, Lucinda;Gabriel, Stacey;Gan, Weiniu;Gao, Shanshan;Gao, Yan;Gass, Margery;Geiger, Heather;Gelb, Bruce;Geraci, Mark;Germer, Soren;Gerszten, Robert;Ghosh, Auyon;Gibbs, Richard;Gignoux, Chris;Gladwin, Mark;Glahn, David;Gogarten, Stephanie;Gong, Da-Wei;Goring, Harald;Graw, Sharon;Gray, Kathryn J.;Grine, Daniel;Gross, Colin;Gu, C. Charles;Guan, Yue;Guo, Xiuqing;Gupta, Namrata;Haessler, Jeff;Hall, Michael;Han, Yi;Hanly, Patrick;Harris, Daniel;Hawley, Nicola L.;He, Jiang;Heavner, Ben;Heckbert, Susan;Hernandez, Ryan;Herrington, David;Hersh, Craig;Hidalgo, Bertha;Hixson, James;Hobbs, Brian;Hokanson, John;Hong, Elliott;Hoth, Karin;Hsiung, Chao (Agnes);Hu, Jianhong;Hung, Yi-Jen;Huston, Haley;Hwu, Chii Min;Irvin, Marguerite Ryan;Jackson, Rebecca;Jain, Deepti;Jaquish, Cashell;Johnsen, Jill;Johnson, Craig;Johnston, Rich;Jones, Kimberly;Kang, Hyun Min;Kaplan, Robert;Kardia, Sharon;Kelly, Shannon;Kenny, Eimear;Kessler, Michael;Khan, Alyna;Khan, Ziad;Kim, Wonji;Kimoff, John;Kinney, Greg;Konkle, Barbara;Kooperberg, Charles;Kramer, Holly;Lange, Christoph;Lange, Ethan;Lange, Leslie;Laurie, Cathy;Laurie, Cecelia;LeBoff, Meryl;Lee, Jiwon;Lee, Sandra;Lee, Wen-Jane;LeFaive, Jonathon;Levine, David;Lewis, Joshua;Li, Xiaohui;Li, Yun;Lin, Henry;Lin, Honghuang;Lin, Xihong;Liu, Simin;Liu, Yongmei;Liu, Yu;Loos, Ruth J. F.;Lubitz, Steven;Lunetta, Kathryn;Luo, James;Magalang, Ulysses;Mahaney, Michael;Make, Barry;Manichaikul, Ani;Manning, Alisa;Manson, JoAnn;Martin, Lisa;Marton, Melissa;Mathai, Susan;Mathias, Rasika;May, Susanne;McArdle, Patrick;McDonald, Merry-Lynn;McFarland, Sean;McGarvey, Stephen;McGoldrick, Daniel;McHugh, Caitlin;McNeil, Becky;Mei, Hao;Meigs, James;Menon, Vipin;Mestroni, Luisa;Metcalf, Ginger;Meyers, Deborah A.;Mignot, Emmanuel;Mikulla, Julie;Min, Nancy;Minear, Mollie;Minster, Ryan L.;Mitchell, Braxton D.;Moll, Matt;Momin, Zeineen;Montasser, May E.;Montgomery, Courtney;Muzny, Donna;Mychaleckyj, Josyf C.;Nadkarni, Girish;Naik, Rakhi;Naseri, Take;Nekhai, Sergei;Nelson, Sarah C.;Neltner, Bonnie;Nessner, Caitlin;Nickerson, Deborah;Nkechinyere, Osuji;North, Kari;O'Connell, Jeff;O'Connor, Tim;Ochs-Balcom, Heather;Okwuonu, Geoffrey;Pack, Allan;Paik, David T.;Palmer, Nicholette;Pankow, James;Papanicolaou, George;Parker, Cora;Peloso, Gina;Peralta, Juan Manuel;Perez, Marco;Perry, James;Peters, Ulrike;Peyser, Patricia;Phillips, Lawrence S.;Pleiness, Jacob;Pollin, Toni;Post, Wendy;Powers Becker, Julia;Preethi Boorgula, Meher;Preuss, Michael;Psaty, Bruce;Qasba, Pankaj;Qiao, Dandi;Qin, Zhaohui;Rafaels, Nicholas;Raffield, Laura;Rajendran, Mahitha;Rao, D. C.;Rasmussen-Torvik, Laura;Ratan, Aakrosh;Redline, Susan;Reed, Robert;Reeves, Catherine;Regan, Elizabeth;Reiner, Alex;Reupena, Muagututi'a Sefuiva;Rice, Ken;Rich, Stephen;Robillard, Rebecca;Robine, Nicolas;Roden, Dan;Roselli, Carolina;Rotter, Jerome;Ruczinski, Ingo;Runnels, Alexi;Russell, Pamela;Ruuska, Sarah;Ryan, Kathleen;Sabino, Ester Cerdeira;Saleheen, Danish;Salimi, Shabnam;Salvi, Sejal;Salzberg, Steven;Sandow, Kevin;Sankaran, Vijay G.;Santibanez, Jireh;Schwander, Karen;Schwartz, David;Sciurba, Frank;Seidman, Christine;Seidman, Jonathan;Series, Frederic;Sheehan, Vivien;Sherman, Stephanie L.;Shetty, Amol;Shetty, Aniket;Sheu, Wayne Hui-Heng;Shoemaker, M. Benjamin;Silver, Brian;Silverman, Edwin;Skomro, Robert;Smith, Albert Vernon;Smith, Jennifer;Smith, Josh;Smith, Nicholas;Smith, Tanja;Smoller, Sylvia;Snively, Beverly;Snyder, Michael;Sofer, Tamar;Sotoodehnia, Nona;Stilp, Adrienne M.;Storm, Garrett;Streeten, Elizabeth;Su, Jessica Lasky;Sung, Yun Ju;Sylvia, Jody;Szpiro, Adam;Taliun, Daniel;Tang, Hua;Taub, Margaret;Taylor, Kent D.;Taylor, Matthew;Taylor, Simeon;Telen, Marilyn;Thornton, Timothy A.;Threlkeld, Machiko;Tinker, Lesley;Tirschwell, David;Tishkoff, Sarah;Tiwari, Hemant;Tong, Catherine;Tracy, Russell;Tsai, Michael;Vaidya, Dhananjay;van den Berg, David;VandeHaar, Peter;Vrieze, Scott;Walker, Tarik;Wallace, Robert;Walts, Avram;Wang, Fei Fei;Wang, Heming;Wang, Jiongming;Watson, Karol;Watt, Jennifer;Weeks, Daniel E.;Weir, Bruce;Weiss, Scott T.;Weng, Lu-Chen;Wessel, Jennifer;Willer, Cristen;Williams, Kayleen;Williams, L. Keoki;Williams, Scott;Wilson, Carla;Wilson, James;Winterkorn, Lara;Wong, Quenna;Wu, Joseph;Xu, Huichun;Yanek, Lisa;Yang, Ivana;Yu, Ketian;Zhang, Yingze;Zhao, Snow Xueyan;Zhao, Wei;Zhu, Xiaofeng;Ziv, Elad;Zody, Michael;Zoellner, Sebastian
慢性肝病是世界范围内的一个主要公共卫生负担。尽管存在不同的肝损伤病因和机制，但慢性肝病的进展遵循肝脏炎症、损伤和纤维化的共同途径。在这里，我们研究了来自4个独立队列的214,563名个体的不确定潜力克隆造血（CHIP）与慢性肝病之间的关系，这些个体具有全外显子组测序数据（Framingham心脏研究、社区动脉粥样硬化风险研究、UK Biobank和Mass General Brigham Biobank）。CHIP与流行和发生慢性肝病的风险增加相关(优势比= 2.01,95%可信区间（95% CI） [1.46, 2.79]；P < 0.001)。与没有CHIP的患者相比，CHIP患者更容易表现出磁共振成像检测到的肝脏炎症和纤维化（优势比= 1.74,95% CI [1.16, 2.60]; P = 0.007）。为了评估潜在的因果关系，孟德尔随机化分析显示，CHIP的遗传易感性与慢性肝病的高风险相关（优势比= 2.37,95% CI [1.57, 3.6]; P < 0.001）。在非酒精性脂肪性肝炎的饮食模型中，移植了tet2缺陷造血细胞的小鼠表现出更严重的肝脏炎症和纤维化。这些作用是由NLRP3炎性小体和tet2缺陷巨噬细胞中下游炎症细胞因子表达水平升高介导的。总之，克隆造血通过异常的炎症反应与肝脏炎症和慢性肝病进展的风险升高相关。
Chronic liver disease is a major public health burden worldwide. Although different aetiologies and mechanisms of liver injury exist, progression of chronic liver disease follows a common pathway of liver inflammation, injury and fibrosis. Here we examined the association between clonal haematopoiesis of indeterminate potential (CHIP) and chronic liver disease in 214,563 individuals from 4 independent cohorts with whole-exome sequencing data (Framingham Heart Study, Atherosclerosis Risk in Communities Study, UK Biobank and Mass General Brigham Biobank). CHIP was associated with an increased risk of prevalent and incident chronic liver disease (odds ratio = 2.01, 95% confidence interval (95% CI) [1.46, 2.79]; P < 0.001). Individuals with CHIP were more likely to demonstrate liver inflammation and fibrosis detectable by magnetic resonance imaging compared to those without CHIP (odds ratio = 1.74, 95% CI [1.16, 2.60]; P = 0.007). To assess potential causality, Mendelian randomization analyses showed that genetic predisposition to CHIP was associated with a greater risk of chronic liver disease (odds ratio = 2.37, 95% CI [1.57, 3.6]; P < 0.001). In a dietary model of non-alcoholic steatohepatitis, mice transplanted with Tet2-deficient haematopoietic cells demonstrated more severe liver inflammation and fibrosis. These effects were mediated by the NLRP3 inflammasome and increased levels of expression of downstream inflammatory cytokines in Tet2-deficient macrophages. In summary, clonal haematopoiesis is associated with an elevated risk of liver inflammation and chronic liver disease progression through an aberrant inflammatory response.
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影响因子：
64.8
作者：
Bick AG;Weinstock JS;Nandakumar SK;Fulco CP;Bao EL;Zekavat SM;Szeto MD;Liao X;Leventhal MJ;Nasser J;Chang K;Laurie C;Burugula BB;Gibson CJ;Lin AE;Taub MA;Aguet F;Ardlie K;Mitchell BD;Barnes KC;Moscati A;Fornage M;Redline S;Psaty BM;Silverman EK;Weiss ST;Palmer ND;Vasan RS;Burchard EG;Kardia SLR;He J;Kaplan RC;Smith NL;Arnett DK;Schwartz DA;Correa A;de Andrade M;Guo X;Konkle BA;Custer B;Peralta JM;Gui H;Meyers DA;McGarvey ST;Chen IY;Shoemaker MB;Peyser PA;Broome JG;Gogarten SM;Wang FF;Wong Q;Montasser ME;Daya M;Kenny EE;North KE;Launer LJ;Cade BE;Bis JC;Cho MH;Lasky-Su J;Bowden DW;Cupples LA;Mak ACY;Becker LC;Smith JA;Kelly TN;Aslibekyan S;Heckbert SR;Tiwari HK;Yang IV;Heit JA;Lubitz SA;Johnsen JM;Curran JE;Wenzel SE;Weeks DE;Rao DC;Darbar D;Moon JY;Tracy RP;Buth EJ;Rafaels N;Loos RJF;Durda P;Liu Y;Hou L;Lee J;Kachroo P;Freedman BI;Levy D;Bielak LF;Hixson JE;Floyd JS;Whitsel EA;Ellinor PT;Irvin MR;Fingerlin TE;Raffield LM;Armasu SM;Wheeler MM;Sabino EC;Blangero J;Williams LK;Levy BD;Sheu WH;Roden DM;Boerwinkle E;Manson JE;Mathias RA;Desai P;Taylor KD;Johnson AD;NHLBI Trans-Omics for Precision Medicine Consortium;Auer PL;Kooperberg C;Laurie CC;Blackwell TW;Smith AV;Zhao H;Lange E;Lange L;Rich SS;Rotter JI;Wilson JG;Scheet P;Kitzman JO;Lander ES;Engreitz JM;Ebert BL;Reiner AP;Jaiswal S;Abecasis G;Sankaran VG;Kathiresan S;Natarajan P
通讯作者：
Natarajan P
DOI：
10.1056/nejmoa1409405
发表时间：
2014-12-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Genovese G;Kähler AK;Handsaker RE;Lindberg J;Rose SA;Bakhoum SF;Chambert K;Mick E;Neale BM;Fromer M;Purcell SM;Svantesson O;Landén M;Höglund M;Lehmann S;Gabriel SB;Moran JL;Lander ES;Sullivan PF;Sklar P;Grönberg H;Hultman CM;McCarroll SA
通讯作者：
McCarroll SA
影响因子：
30.8
作者：
Chen J;Spracklen CN;Marenne G;Varshney A;Corbin LJ;Luan J;Willems SM;Wu Y;Zhang X;Horikoshi M;Boutin TS;Mägi R;Waage J;Li-Gao R;Chan KHK;Yao J;Anasanti MD;Chu AY;Claringbould A;Heikkinen J;Hong J;Hottenga JJ;Huo S;Kaakinen MA;Louie T;März W;Moreno-Macias H;Ndungu A;Nelson SC;Nolte IM;North KE;Raulerson CK;Ray D;Rohde R;Rybin D;Schurmann C;Sim X;Southam L;Stewart ID;Wang CA;Wang Y;Wu P;Zhang W;Ahluwalia TS;Appel EVR;Bielak LF;Brody JA;Burtt NP;Cabrera CP;Cade BE;Chai JF;Chai X;Chang LC;Chen CH;Chen BH;Chitrala KN;Chiu YF;de Haan HG;Delgado GE;Demirkan A;Duan Q;Engmann J;Fatumo SA;Gayán J;Giulianini F;Gong JH;Gustafsson S;Hai Y;Hartwig FP;He J;Heianza Y;Huang T;Huerta-Chagoya A;Hwang MY;Jensen RA;Kawaguchi T;Kentistou KA;Kim YJ;Kleber ME;Kooner IK;Lai S;Lange LA;Langefeld CD;Lauzon M;Li M;Ligthart S;Liu J;Loh M;Long J;Lyssenko V;Mangino M;Marzi C;Montasser ME;Nag A;Nakatochi M;Noce D;Noordam R;Pistis G;Preuss M;Raffield L;Rasmussen-Torvik LJ;Rich SS;Robertson NR;Rueedi R;Ryan K;Sanna S;Saxena R;Schraut KE;Sennblad B;Setoh K;Smith AV;Sparsø T;Strawbridge RJ;Takeuchi F;Tan J;Trompet S;van den Akker E;van der Most PJ;Verweij N;Vogel M;Wang H;Wang C;Wang N;Warren HR;Wen W;Wilsgaard T;Wong A;Wood AR;Xie T;Zafarmand MH;Zhao JH;Zhao W;Amin N;Arzumanyan Z;Astrup A;Bakker SJL;Baldassarre D;Beekman M;Bergman RN;Bertoni A;Blüher M;Bonnycastle LL;Bornstein SR;Bowden DW;Cai Q;Campbell A;Campbell H;Chang YC;de Geus EJC;Dehghan A;Du S;Eiriksdottir G;Farmaki AE;Frånberg M;Fuchsberger C;Gao Y;Gjesing AP;Goel A;Han S;Hartman CA;Herder C;Hicks AA;Hsieh CH;Hsueh WA;Ichihara S;Igase M;Ikram MA;Johnson WC;Jørgensen ME;Joshi PK;Kalyani RR;Kandeel FR;Katsuya T;Khor CC;Kiess W;Kolcic I;Kuulasmaa T;Kuusisto J;Läll K;Lam K;Lawlor DA;Lee NR;Lemaitre RN;Li H;Lifelines Cohort Study;Lin SY;Lindström J;Linneberg A;Liu J;Lorenzo C;Matsubara T;Matsuda F;Mingrone G;Mooijaart S;Moon S;Nabika T;Nadkarni GN;Nadler JL;Nelis M;Neville MJ;Norris JM;Ohyagi Y;Peters A;Peyser PA;Polasek O;Qi Q;Raven D;Reilly DF;Reiner A;Rivideneira F;Roll K;Rudan I;Sabanayagam C;Sandow K;Sattar N;Schürmann A;Shi J;Stringham HM;Taylor KD;Teslovich TM;Thuesen B;Timmers PRHJ;Tremoli E;Tsai MY;Uitterlinden A;van Dam RM;van Heemst D;van Hylckama Vlieg A;van Vliet-Ostaptchouk JV;Vangipurapu J;Vestergaard H;Wang T;Willems van Dijk K;Zemunik T;Abecasis GR;Adair LS;Aguilar-Salinas CA;Alarcón-Riquelme ME;An P;Aviles-Santa L;Becker DM;Beilin LJ;Bergmann S;Bisgaard H;Black C;Boehnke M;Boerwinkle E;Böhm BO;Bønnelykke K;Boomsma DI;Bottinger EP;Buchanan TA;Canouil M;Caulfield MJ;Chambers JC;Chasman DI;Chen YI;Cheng CY;Collins FS;Correa A;Cucca F;de Silva HJ;Dedoussis G;Elmståhl S;Evans MK;Ferrannini E;Ferrucci L;Florez JC;Franks PW;Frayling TM;Froguel P;Gigante B;Goodarzi MO;Gordon-Larsen P;Grallert H;Grarup N;Grimsgaard S;Groop L;Gudnason V;Guo X;Hamsten A;Hansen T;Hayward C;Heckbert SR;Horta BL;Huang W;Ingelsson E;James PS;Jarvelin MR;Jonas JB;Jukema JW;Kaleebu P;Kaplan R;Kardia SLR;Kato N;Keinanen-Kiukaanniemi SM;Kim BJ;Kivimaki M;Koistinen HA;Kooner JS;Körner A;Kovacs P;Kuh D;Kumari M;Kutalik Z;Laakso M;Lakka TA;Launer LJ;Leander K;Li H;Lin X;Lind L;Lindgren C;Liu S;Loos RJF;Magnusson PKE;Mahajan A;Metspalu A;Mook-Kanamori DO;Mori TA;Munroe PB;Njølstad I;O'Connell JR;Oldehinkel AJ;Ong KK;Padmanabhan S;Palmer CNA;Palmer ND;Pedersen O;Pennell CE;Porteous DJ;Pramstaller PP;Province MA;Psaty BM;Qi L;Raffel LJ;Rauramaa R;Redline S;Ridker PM;Rosendaal FR;Saaristo TE;Sandhu M;Saramies J;Schneiderman N;Schwarz P;Scott LJ;Selvin E;Sever P;Shu XO;Slagboom PE;Small KS;Smith BH;Snieder H;Sofer T;Sørensen TIA;Spector TD;Stanton A;Steves CJ;Stumvoll M;Sun L;Tabara Y;Tai ES;Timpson NJ;Tönjes A;Tuomilehto J;Tusie T;Uusitupa M;van der Harst P;van Duijn C;Vitart V;Vollenweider P;Vrijkotte TGM;Wagenknecht LE;Walker M;Wang YX;Wareham NJ;Watanabe RM;Watkins H;Wei WB;Wickremasinghe AR;Willemsen G;Wilson JF;Wong TY;Wu JY;Xiang AH;Yanek LR;Yengo L;Yokota M;Zeggini E;Zheng W;Zonderman AB;Rotter JI;Gloyn AL;McCarthy MI;Dupuis J;Meigs JB;Scott RA;Prokopenko I;Leong A;Liu CT;Parker SCJ;Mohlke KL;Langenberg C;Wheeler E;Morris AP;Barroso I;Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC)
通讯作者：
Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC)
影响因子：
13.5
作者：
Csak, Timea;Ganz, Michal;Pespisa, Justin;Kodys, Karen;Dolganiuc, Angela;Szabo, Gyongyi
通讯作者：
Szabo, Gyongyi
影响因子：
24.5
作者：
Krenkel, Oliver;Hundertmark, Jana;Tacke, Frank
通讯作者：
Tacke, Frank