Regional brain activation during verbal declarative memory in metastatic breast cancer.
Regional brain activation during verbal declarative memory in metastatic breast cancer.
复制标题
DOI：
10.1158/1078-0432.ccr-09-1227
复制
发表时间：
2009-11-01
期刊：
影响因子：
--
通讯作者：
Spiegel D
中科院分区：
文献类型：
--
作者：
Kesler SR;Bennett FC;Mahaffey ML;Spiegel D
确定转移性乳腺癌女性患者言语记忆功能障碍的神经功能基础。这一目标是基于以前的研究表明，在这一人群中的记忆和其他认知缺陷。我们试图确定语言记忆障碍是否与最常研究的疾病参数相关，包括辅助化疗和慢性应激相关的边缘系统结构破坏。我们利用功能性磁共振成像（fMRI）来验证我们的假设，即与年龄和教育程度匹配的健康女性对照组相比，乳腺癌女性在口头陈述性记忆任务中的大脑激活显着降低。我们还评估了几个与压力相关的变量，包括昼夜皮质醇水平，以验证我们的假设，即乳腺癌女性会表现出更高的压力，这将有助于记忆任务期间的大脑激活缺陷。与对照组相比，乳腺癌患者在记忆编码条件下前额叶皮层的激活明显较低。然而，乳腺癌组在多个弥散性脑区的回忆条件下表现出比对照组显著更大的激活。两组在压力相关变量上没有显著差异。接受CMF化疗的女性在记忆编码过程中表现出较低的前额叶皮层激活。这些结果表明，转移性乳腺癌妇女可能有语言记忆障碍的风险，这是由于功能性脑激活谱的改变。这些发现可能与化疗类型和/或乳腺癌疾病过程的其他方面有关。
To determine the neurofunctional basis of verbal memory dysfunction in women with metastatic breast cancer. This objective was based on previous research suggesting memory and other cognitive deficits in this population. We attempted to determine if verbal memory impairments were related to the most commonly studied disease parameters including adjuvant chemotherapy and chronic stress-related disruption of limbic system structures. We utilized functional magnetic resonance imaging (fMRI) to test our hypothesis that women with breast cancer would demonstrate significantly lower brain activation during a verbal declarative memory tasks compared to age and education-matched healthy female controls. We also assessed several stress-related variables including diurnal cortisol levels to test our hypothesis that women with breast cancer would demonstrate higher stress and this would contribute to brain activation deficits during memory tasks. Women with breast cancer had significantly lower prefrontal cortex activation during the memory encoding condition compared to controls. However, the breast cancer group demonstrated significantly greater activation than controls during the recall condition in multiple, diffuse brain regions. There were no significant differences between the groups in stress-related variables. Women who were treated with CMF chemotherapy demonstrated lower prefrontal cortex activation during memory encoding. These results suggest that women with metastatic breast cancer may be at risk for verbal memory impairments as a result of altered functional brain activation profiles. These findings may be associated with chemotherapy type and/or other aspects of the breast cancer disease process.