Changes in functional connectivity related to direct training and generalization effects of a word finding treatment in chronic aphasia.
Changes in functional connectivity related to direct training and generalization effects of a word finding treatment in chronic aphasia.
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DOI：
10.1016/j.bandl.2015.09.002
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发表时间：
2015-11
影响因子：
2.5
通讯作者：
Kiran S
中科院分区：
文献类型：
--
作者：
Sandberg CW;Bohland JW;Kiran S
在失语症患者（PWA）中，治疗诱导的词语发现能力改善的神经机制目前尚不清楚。本研究旨在揭示失语症中功能网络连通性的变化。为此，我们使用功能磁共振成像和图论分析来检查基于理论的词查找处理后功能连接的变化，其中抽象词被用作训练项目，目的是促进对具体词的概括。10名母语为英语的右撇子PWA（男7名，女3名），年龄47 ~ 75岁，平均59岁。直接训练的效果与涉及抽象文字处理的区域的功能连通性增加相一致。泛化效应与具体文字处理区域的功能连通性增加相一致。重要的是，训练和泛化效应之间的相似性被注意到，而泛化和不泛化的参与者之间的差异也被注意到。
The neural mechanisms that underlie generalization of treatment-induced improvements in word finding in persons with aphasia (PWA) are currently poorly understood. This study aimed to shed light on changes in functional network connectivity underlying generalization in aphasia. To this end, we used fMRI and graph theoretic analyses to examine changes in functional connectivity after a theoretically-based word-finding treatment in which abstract words were used as training items with the goal of promoting generalization to concrete words. Ten right-handed native English-speaking PWA (7 male, 3 female) ranging in age from 47 to 75 (mean = 59) participated in this study. Direct training effects coincided with increased functional connectivity for regions involved in abstract word processing. Generalization effects coincided with increased functional connectivity for regions involved in concrete word processing. Importantly, similarities between training and generalization effects were noted as were differences between participants who generalized and those who did not.