RIFAMPICIN AND VITAMIN-D METABOLISM
RIFAMPICIN AND VITAMIN-D METABOLISM
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DOI：
10.1038/clpt.1980.115
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发表时间：
1980-01-01
影响因子：
6.7
通讯作者：
PARK, BK
中科院分区：
文献类型：
--
作者：
BRODIE, MJ;BOOBIS, AR;PARK, BK
在8名男性[人]受试者中口服（600 mg/天）酶诱导抗生素利福平的2周疗程导致血浆25-羟基胆钙化醇（25-OHD）水平持续下降约70%，伴随着安替比林和6 β-羟胆钙化醇的氧化增加。羟基皮质醇（指示肝酶诱导）。血浆1，25-二羟胆钙化醇、甲状旁腺激素和降钙素水平未发生变化。25-OHD的下降可能代表药物性骨软化的最早病变。
A 2 wk course of the enzyme inducing antibiotic rifampicin orally (600 mg/day) in 8 male [human] subjects resulted in a consistent fall in plasma 25-hydroxycholecalciferol (25-OHD) levels of around 70%, accompanied by increased oxidation of antipyrine and 6.beta.-hydroxycortisol (indicative of hepatic enzyme induction). Plasma levels of 1,25-dihydroxycholecalciferol, parathyroid hormone and calcitonin were not altered. The fall in 25-OHD may represent the earliest lesion of drug-induced osteomalacia.