The Neonatal Salivary Transcriptome
The Neonatal Salivary Transcriptome
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DOI：
10.1101/cshperspect.a026369
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发表时间：
2016-03-01
影响因子：
5.4
通讯作者：
Maron, Jill L.
中科院分区：
文献类型：
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作者：
Maron, Jill L.
能够非侵入性地评估新生儿的身体和发育状态是现代医学的目标。近年来，技术的进步已经允许从单个样本来源中对唾液进行高通量分析，以获得数千种基因、蛋白质和代谢物。唾液是评估新生儿健康、疾病和发育的理想生物流体。它可以反复使用，即使是在最脆弱的患者中，也没有伤害的风险。通过唾液转录组将有关婴儿整体发育和疾病风险的新信息翻译到新生儿床边，有可能显着改善这一高危人群的临床护理和结局。
The ability to noninvasively assess the physical and developmental status of a neonate is a goal of modern medicine. In recent years, technological advances have permitted the high-throughput analysis of saliva for thousands of genes, proteins, and metabolites from a single sample source. Saliva is an ideal biofluid to assess health, disease, and development in the newborn. It may be harnessed repeatedly, even in the most vulnerable patients, without risk of harm. Translating novel information about an infant's global development and risk of disease to the neonatal bedside through the salivary transcriptome has the potential to significantly improve clinical care and outcomes in this at-risk population.