Thalamic and temporal cortex input to medial prefrontal cortex in rhesus monkeys
Thalamic and temporal cortex input to medial prefrontal cortex in rhesus monkeys
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DOI：
10.1007/pl00005713
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发表时间：
1997-07-01
影响因子：
2
通讯作者：
Ungerleider, LG
中科院分区：
文献类型：
--
作者：
Bachevalier, J;Meunier, M;Ungerleider, LG
为了确定丘脑输入到内侧方面的前额叶皮质的来源，我们注射逆行示踪剂（麦胚凝集素结合辣根过氧化物酶，核黄，和/或bisbenzimide）到7个内侧前额叶网站和顺行示踪剂（氚化氨基酸）到6个丘脑网站，在总共9只猕猴。结果表明，胼胝体腹侧前区和胼胝体下区14、25，以及胼胝体腹侧下区32，均接受内侧背核大细胞部内侧背侧部的投射。区域32的背侧胼胝体前部分主要接收来自内侧背核（MDpc）的小细胞部的背侧部分的投射，其也向区域14提供一些输入。极区10接收来自MDpc和内侧背核（MDdc）的致密细胞分裂的输入，胼胝体上区24也是如此。区域24接收来自前内侧核和中线核的附加输入。所有内侧前额叶皮质区也被发现接受来自颞叶内的一些皮质区域的投射，如颞极、上级颞回和海马旁回。此外，24、25和32区还接收来自内嗅皮层的输入。结合这些结果与以前的解剖和行为数据，我们得出结论，内侧颞区是重要的对象识别记忆直接发送信息到背内侧前额叶区24和32和腹内侧前额叶区14和25。只有后两个区域才能通过MDmc中背侧部分的投影额外获取此信息。
To determine the source of thalamic input to the medial aspect of the prefrontal cortex, we injected retrograde tracers (wheat germ agglutinin conjugated to horseradish peroxidase, nuclear yellow, and/or bisbenzimide) into seven medial prefrontal sites and anterograde tracers (tritiated amino acids) into six thalamic sites, in a total of nine rhesus monkeys. The results indicated that ventral precallosal and subcallosal areas 14 and 25, and the ventral, subcallosal parr of area 32, all receive projections from the mediodorsal portion of the magnocellular division of the medial dorsal nucleus (MDmc). The dorsal, precallosal part of area 32 receives projections mainly from the dorsal portion of the parvocellular division of the medial dorsal nucleus (MDpc), which also provides some input to area 14. Polar area 10 receives input from both MDpc and the densocellular division of the medial dorsal nucleus (MDdc), as does supracallosal area 24. Area 24 receives additional input from the anterior medial nucleus and midline nuclei. All medial prefrontal cortical areas were also found to receive projections from a number of cortical regions within the temporal lobe, such as the temporal pole, superior temporal gyrus, and parahippocampal gyrus. Areas 24, 25, and 32 receive, in addition, input from the entorhinal cortex. Combining these results with prior anatomical and behavioral data, we conclude that medial temporal areas that are important for object recognition memory send information directly both to dorsal medial prefrontal areas 24 and 32 and to ventral medial prefrontal areas 14 and 25. Only the latter two areas have additional access to this information via projections from the mediodorsal part of MDmc.