Association of night-time sleep and day napping with the prevalence of MOSH in young obese men
Association of night-time sleep and day napping with the prevalence of MOSH in young obese men
复制标题
年轻肥胖男性夜间睡眠和白天小睡与 MOSH 患病率的关系
作者：
Chen Yufei;Zhang Ling;Zhao Shaoqian;Yuan Lihui;Shi Juan;Zhang Yifei;Wang Jiqiu;Gu Weiqiong;Wang Weiqing;Hong Jie
男性肥胖也被证明与生殖潜能降低有关，这种特殊亚型被描述为男性肥胖相关的继发性性腺功能减退（MOSH）。最近的研究表明，睡眠障碍对睾酮水平的影响表明，睡眠障碍在决定MOSH发展中的潜在作用。目的评估夜间睡眠时间和日间小睡与MOSH患病率之间的关系。材料和方法在这项横断面研究中，226名年龄在18-30岁的肥胖男性被纳入研究。白天午睡和夜间睡眠时间的数据采用标准化的自报告中文问卷收集。MOSH定义为肥胖男性（BMI≥30 kg/m2），伴有性腺功能减退症状，总睾酮水平和/或游离睾酮水平下降，排除其他性腺功能减退的原因。结果本组MOSH总患病率为48.2%。夜间睡眠时间与MOSH患病率呈负相关。报告夜间睡眠时间少于6小时的男性总睾酮和游离睾酮水平降低，MOSH的风险增加。进一步的回归分析显示，在校正潜在混杂因素后，短睡眠组（<6小时vs. 6 - 8小时）MOSH的比值比为6.17 （p= 0.040）。没有观察到白天午睡状态与MOSH患病率之间的显著关联。讨论与结论在中国年轻肥胖人群中，夜间睡眠时间短与MOSH风险增加有关。就性腺功能减退而言，长期睡眠不足对肥胖男性的健康有负面影响。
BackgroundObesity in men is also shown to be associated with reduced reproductive potential, and this particular subtype was described as male obesity‐associated secondary hypogonadism (MOSH). Recent studies showing the influence of sleep disorders on testosterone levels suggested a potential role of sleep disorders in determining the development of MOSH.ObjectivesTo assess the association between night‐time sleep duration and day napping and the prevalence of MOSH.Materials and methodsIn this cross‐sectional study, 226 obese male participants aged 18–30 years were enrolled. Daytime napping and night‐time sleep duration data were collected using a standardized self‐reported Chinese‐language questionnaire. MOSH was defined as obese men (BMI ≥ 30 kg/m2) with hypogonadal symptoms and decreased total testosterone level and/or free testosterone level, excluding other causes of hypogonadism.ResultsThe overall prevalence of MOSH was 48.2% in this study. An inverse association was observed between night sleep duration and the risk of prevalent MOSH. Men who reported fewer than 6 h of night‐time sleep had reduced total testosterone and free testosterone levels and an increased risk of MOSH. Further regression analysis revealed that after adjustment for potential confounders, the odds ratio of MOSH for the short night‐time sleep group (<6 h vs. 6–8 h) was 6.17 (p= 0.040). No significant association was observed between day napping status and prevalence of MOSH.Discussion and conclusionShort night sleep duration was associated with an increased risk of MOSH in the young obese Chinese population. Chronic sleep curtailment has a negative effect on obese men's health in terms of hypogonadism.