Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility
Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility
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DOI：
10.1037/0735-7044.120.2.298
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发表时间：
2006-04-01
影响因子：
1.9
通讯作者：
Butt, AE
中科院分区：
文献类型：
--
作者：
Cabrera, SM;Chavez, CM;Butt, AE
作者检验了胆碱能大细胞基底核（NBM）参与解决需要认知灵活性的问题的假设。评估具有NBM的192个IgG-皂草素损伤的大鼠的持续性（即，认知不灵活性）在操作性歧视的连续逆转和随后的消退测试期间。据推测，NBM病变组和对照组在获得初始的，简单的歧视方面没有差异，因为这项任务不需要认知灵活性。相反，假设NBM病变组在连续逆转和消退试验期间显示持续性。结果普遍支持这些假设，这表明，NBM起着重要的作用，在调解认知灵活性。
The authors tested the hypothesis that the cholinergic nucleus basalis magnocellularis (NBM) is involved in solving problems requiring cognitive flexibility. Rats with 192 IgG-saporin lesions of the NBM were assessed for perseveration (i.e., cognitive inflexibility) in the serial reversal of an operant discrimination and during subsequent extinction testing. It was hypothesized that the NBM lesion and control groups would not differ in the acquisition of the initial, simple discrimination, because this task does not demand cognitive flexibility. In contrast, it was hypothesized that the NBM lesion group would show perseveration during serial reversal and extinction testing. Results generally supported these hypotheses, suggesting that the NBM plays an important role in mediating cognitive flexibility.