Early asymmetry of gene transcription in embryonic human left and right cerebral cortex
Early asymmetry of gene transcription in embryonic human left and right cerebral cortex
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DOI：
10.1126/science.1110324
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发表时间：
2005-06-17
期刊：
影响因子：
56.9
通讯作者：
Walsh, CA
中科院分区：
文献类型：
--
作者：
Sun, T;Patoine, C;Walsh, CA
人类的左右大脑半球在解剖学和功能上是不对称的。为了测试人类大脑皮层不对称是否有分子基础，我们使用基因表达系列分析（SAGE）研究了左右胚胎半球之间的基因表达水平。我们鉴定并验证了27个差异表达基因，这表明人类大脑皮层的不对称性伴随着早期显著的转录不对称性。LMO4在右侧大脑外侧裂周围的人类大脑皮层中的表达始终比左侧高，并且对小鼠的皮层发育至关重要，这表明人类左右特化反映了早期阶段的不对称皮层发育。
The human left and right cerebral hemispheres are anatomically and functionally asymmetric. To test whether human cortical asymmetry has a molecular basis, we studied gene expression levels between the left and right embryonic hemispheres using serial analysis of gene expression (SAGE). We identified and verified 27 differentialty expressed genes, which suggests that human cortical asymmetry is accompanied by early, marked transcriptional asymmetries. LMO4 is consistently more highly expressed in the right perisylvian human cerebral cortex than in the left and is essential for cortical development in mice, suggesting that human left-right specialization reflects asymmetric cortical development at early stages.