Study of Experimental Cervical Spondylotic Myelopathy
Study of Experimental Cervical Spondylotic Myelopathy
复制标题
实验性脊髓型颈椎病的研究
DOI：
10.1097/00007632-199210001-00007
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发表时间：
1992
期刊：
影响因子：
3
通讯作者：
K. Furuya
中科院分区：
文献类型：
--
作者：
K. Shinomiya;N. Mutoh;K. Furuya
大多数脊髓型颈椎病发病隐匿。用猫制作实验性脊髓型颈椎病模型，分析脊髓脊髓病的进展模式，并确定最主要的因素。前路使用一颗螺钉穿过C5椎体或三颗螺钉穿过C4、C5和C6椎体进行脊髓压迫。每隔几周，螺丝钉一次旋转约1毫米，最多可旋转50%的椎管。在最终压迫后6个月以上，评估肢体功能和脊髓诱发电位。结果：单次压迫组肢体功能正常，多次压迫组步态迟缓。组织学上，单压迫组灰质轻度神经元减少明显。相反，多次压迫组表现出严重的灰质改变，后柱和前柱明显改变。脊髓诱发电位与组织学变化有相关性。很明显，与单一压迫相比，对脊髓的多次压迫在功能、电生理和组织学上引起更严重的恶化。
Most cervical spondylotic myelopathy cases show insidious onset. Experimental cervical spondylotic myelopathy models were made using cats to analyze advancing patterns of myelopathy in the spinal cord and to identify the most responsible factor. Spinal cord compression was applied anteriorly using one screw through the C5 vertebral body or three screws through the C4, C5, and C6 vertebral bodies. Every few weeks, the screws were turned approximately 1mm at a time up to approximately 50% of the spinal canal. At more the 6 months after final compression, limb function and evoked spinal cord potentials were evaluated. The results: the single compression group showed normal limb function, but the multiple compression group showed sluggish gait. Histologically, mild neuronal decrease in the gray matter was noticeable in the single compression group. Conversely, the multiple compression group showed severe changes in the gray matter and significant changes in the posterior and anterior columns. There was a correlation between the evoked spinal cord potentials and histologic changes. It was clear that multiple compressions to the spinal cord caused more severe deterioration functionally and electrophysiologically as well as histologically than a single compression.