INFLUENCE OF PROTEIN INGESTION ON HUMAN SPLANCHNIC AND WHOLE-BODY OXYGEN-CONSUMPTION, BLOOD-FLOW, AND BLOOD TEMPERATURE
INFLUENCE OF PROTEIN INGESTION ON HUMAN SPLANCHNIC AND WHOLE-BODY OXYGEN-CONSUMPTION, BLOOD-FLOW, AND BLOOD TEMPERATURE
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DOI：
10.1016/0026-0495(94)90206-2
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发表时间：
1994-05-01
影响因子：
9.8
通讯作者：
WAHREN, J
中科院分区：
文献类型：
--
作者：
BRUNDIN, T;WAHREN, J
对10名健康受试者口服900kJ鱼蛋白前和后2小时的内脏和全身摄氧量、血流量和血温进行了研究。使用间接量热法和导管技术，包括动脉、肺动脉和肝静脉血的血温测量。餐后肺摄氧量由基础值272±11升至332±23毫升/分。在餐后1小时内，内脏摄氧量由62±5升至93±9毫升/分(+50%，P<；0.05)，占同期整体耗氧量增加的62%±17%。在餐后第二个小时，内脏摄氧量不再进一步增加，而内脏外组织的耗氧量增加，现在占整个同时增加的肺摄氧量。心输出量由基础的6.4±0.4增加到7.5±0.5 L/min。内脏血流量变化不大，而肝动脉血氧差从46±3增加到54±4毫升/L，动脉和肝静脉血液温度增加了近0.3°C，反映了相当大的热量积累，表明转换为正的热平衡。结果表明，摄取蛋白质后，(1)摄氧量在1小时内主要在内脏器官增加，此后仅在内脏外组织中增加；(2)血流量主要在内脏外组织中增加；(3)血液温度几乎呈线性上升，表明中央温度传感器的温度设定点上升。
Splanchnic and whole-body oxygen uptake, blood flow, and blood temperature were studied in 10 healthy subjects before and during 2 hours after oral ingestion of 900 kJ of fish protein. Indirect calorimetry and catheter techniques were used, including blood thermometry in arterial, pulmonary arterial, and hepatic venous blood. After the meal, pulmonary oxygen uptake increased from a basal value of 272 ± 11 to 332 ± 23 mL/min. During the first postprandial hour, splanchnic oxygen uptake increased from 62 ± 5 to 93 ± 9 mL/min (+50%,P< .05), thereby accounting for 62% ± 17% of the simultaneous increase in whole-body oxygen consumption. During the second postprandial hour, splanchnic oxygen uptake increased no further, whereas in the extrasplanchnic tissues the oxygen consumption increased, now accounting for the entire simultaneous increase in pulmonary oxygen uptake. Cardiac output increased from basal 6.4 ± 0.4 to 7.5 ± 0.5 L/min. Splanchnic blood flow changed little while the arteriohepatic venous oxygen difference increased from 46 ± 3 to 54 ± 4 mL/L. Arterial and hepatic venous blood temperatures increased by almost 0.3°C, reflecting a considerable accumulation of heat, indicating a conversion into a positive thermal balance. It is concluded that after protein ingestion, (1) oxygen uptake increases mainly in the splanchnic organs during the first hour, and thereafter exclusively in the extrasplanchnic tissues; (2) the blood flow increases mainly in extrasplanchnic tissues; and (3) the blood temperature increases almost linearly, indicating an upward adjustment of the temperature setpoint in the central thermosensors.