Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
复制标题
DOI：
10.1038/417141a
复制
发表时间：
2002-05-09
期刊：
影响因子：
64.8
通讯作者：
Hopwood, DA
中科院分区：
文献类型：
--
作者：
Bentley, SD;Chater, KF;Hopwood, DA
天蓝色链霉菌是一组土壤居住的丝状细菌的代表，负责生产人类和兽医学中使用的大多数天然抗生素。在这里，我们报告了这种生物的8，667，507碱基对线性染色体，包含迄今为止在细菌中发现的最大数量的基因。7，825个预测的基因包括20多个编码已知或预测的次级代谢产物的簇。基因组包含了前所未有的比例的调控基因，主要是那些可能参与对外部刺激和压力的反应，和许多重复的基因集，可能代表“组织特异性”的异构体在不同阶段的殖民发展，一个独特的情况下，细菌。在结核分枝杆菌和白喉棒状杆菌的染色体中心“核心”与整个染色体之间发现了一种古老的同线性。基因组序列将大大增加我们对土壤中微生物生命的了解，并有助于通过基因工程产生新的候选药物。
Streptomyces coelicolor is a representative of the group of soil-dwelling, filamentous bacteria responsible for producing most natural antibiotics used in human and veterinary medicine. Here we report the 8,667, 507 base pair linear chromosome of this organism, containing the largest number of genes so far discovered in a bacterium. The 7,825 predicted genes include more than 20 clusters coding for known or predicted secondary metabolites. The genome contains an unprecedented proportion of regulatory genes, predominantly those likely to be involved in responses to external stimuli and stresses, and many duplicated gene sets that may represent 'tissue-specific' isoforms operating in different phases of colonial development, a unique situation for a bacterium. An ancient synteny was revealed between the central 'core' of the chromosome and the whole chromosome of pathogens Mycobacterium tuberculosis and Corynebacterium diphtheriae. The genome sequence will greatly increase our understanding of microbial life in the soil as well as aiding the generation of new drug candidates by genetic engineering.