Synthesis and Antibacterial Activity of Quaternary Ammonium Salt-Type Antibacterial Agents with a Phosphate Group
Synthesis and Antibacterial Activity of Quaternary Ammonium Salt-Type Antibacterial Agents with a Phosphate Group
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DOI：
10.5650/jos.57.445
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发表时间：
2008-08-01
影响因子：
1.5
通讯作者：
Yoshino, Norio
中科院分区：
文献类型：
--
作者：
Ohta, Yumi;Kondo, Yukishige;Yoshino, Norio
季铵盐经常被用作抗菌剂，它通过其铵离子与细菌外层组织中的阴离子位点结合而破坏细胞膜。本文介绍了以羟基磷灰石为强结合基团，溴离子为反离子的季铵盐型抗菌剂的合成。以最小抑菌浓度（MIC）评价所合成化合物的抑菌活性，结果表明所合成的化合物对革兰氏阳性菌和革兰氏阴性菌、酵母菌和真菌等多种细菌均具有良好的抑菌活性。
Quaternary ammonium salts are frequently used as antibacterial agent that disrupts cell membrane through the binding of their ammonium cations to anionic sites in the outer layer tissue of bacteria. This article describes the synthesis of quaternary ammonium salt-type antibacterial agents with a phosphate group that strongly binds to hydroxyapatite and bromide ion as counterion. Evaluation of the antibacterial activity of the synthesized compounds in terms of minimum inhibitory concentration (MIC test) showed that the compounds exhibit an excellent antibacterial activity on a variety of bacteria including Gram-positive and Gram-negative bacteria, yeast, and fungi.