Perivascular adipose tissue in vascular function and disease: a review of current research and animal models.
Perivascular adipose tissue in vascular function and disease: a review of current research and animal models.
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DOI：
10.1161/atvbaha.114.303029
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发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
Chang L
中科院分区：
文献类型：
--
作者：
Brown NK;Zhou Z;Zhang J;Zeng R;Wu J;Eitzman DT;Chen YE;Chang L
血管周围脂肪组织（PVAT），长期以来被认为只不过是支持血管的结缔组织，现在被认为是血管系统的重要，活跃的组成部分，在血管健康和疾病中起着不可或缺的作用。PVAT是一种与棕色和白色脂肪组织相似的脂肪组织，尽管最近的证据表明PVAT是从其自身的前体发展而来的。像其他脂肪组织库一样，PVAT分泌许多生物活性物质，可以自分泌和旁分泌方式发挥作用。PVAT也被证明参与血管炎症。虽然PVAT可以通过巨噬细胞积累支持动脉粥样硬化期间的炎症，但新出现的证据表明PVAT还具有与其诱导非颤抖性产热和代谢脂肪酸的能力相关的抗动脉粥样硬化特性。本文就PVAT的生物学基础、高血压和动脉粥样硬化模型的相关研究进行综述。
Perivascular adipose tissue (PVAT), long assumed to be nothing more than vessel-supporting connective tissue, is now understood to be an important, active component of the vasculature, with integral roles in vascular health and disease. PVAT is an adipose tissue with similarities to both brown and white adipose tissue, although recent evidence suggests that PVAT develops from its own precursors. Like other adipose tissue depots, PVAT secretes numerous biologically active substances that can act in both autocrine and paracrine fashion. PVAT has also proven to be involved in vascular inflammation. While PVAT can support inflammation during atherosclerosis via macrophage accumulation, emerging evidence suggests that PVAT also has anti-atherosclerotic properties related to its abilities to induce non-shivering thermogenesis and metabolize fatty acids. We here discuss the accumulated knowledge of PVAT biology, and related research on models of hypertension and atherosclerosis.