A neuropeptide FF-related gene is expressed selectively in neurons of the terminal nerve in Danio rerio
A neuropeptide FF-related gene is expressed selectively in neurons of the terminal nerve in Danio rerio
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神经肽FF相关基因在斑马鱼终末神经元中选择性表达
DOI：
10.1016/s0925-4773(02)00210-1
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发表时间：
2002
影响因子：
2.6
通讯作者：
S. I. Korsching
中科院分区：
文献类型：
--
作者：
V. Oehlmann;H. Korte;C. Sterner;S. I. Korsching
RFamide是神经调节多肽的一个大家族。我们克隆了一个斑马鱼基因，该基因可能与哺乳动物的RFamidesPQRF亚家族同源，并根据其种类和亚科分配将其命名为zfPQRF。与哺乳动物不同的是，zfPQRF在端脑的嗅球和嗅视网状核中表达，但在更多的尾部区域表达，包括下丘脑、脑干和脊髓。ZfPQRF表达的神经元起源于嗅觉平台附近，并在发育后期填充到终末神经的核中，斑马鱼鲑鱼型促性腺激素释放激素的共表达证明了这一点，斑马鱼鲑鱼型促性腺激素释放激素被发现专用于标记终末神经细胞。
RFamides constitute a large family of neuromodulatory peptides. We have cloned a zebrafish gene, which is presumably a homologue to the mammalian PQRF subfamily of RFamides, and named it zfPQRF for its species and subfamily allocation. We report that in contrast to its mammalian counterparts zfPQRF is expressed in the olfactory bulb and the nucleus olfactoretinalis in the telencephalon, but absent in more caudal regions, including hypothalamus, brain stem and spinal cord. zfPQRF-expressing neurons originate in the vicinity of the olfactory placode and populate the nuclei of the terminal nerve during later development, as demonstrated by co-expression of zebrafish salmon-type gonadotropin releasing hormone, which was found to exclusively label terminal nerve neurons.
一个生物体中的三个促性腺激素释放激素基因表明了一种古老肽的新作用。
DOI：
10.1073/pnas.92.18.8363
发表时间：
1995
影响因子：
11.1
作者：
White,SA;Kasten,TL;Bond,CT;Adelman,JP;Fernald,RD
通讯作者：
Fernald,RD