High resolution mass spectrometry-based non-target screening can support regulatory environmental monitoring and chemicals management
High resolution mass spectrometry-based non-target screening can support regulatory environmental monitoring and chemicals management
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DOI：
10.1186/s12302-019-0225-x
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发表时间：
2019-07-15
影响因子：
5.9
通讯作者：
Tornero, Victoria
中科院分区：
文献类型：
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作者：
Hollender, Juliane;van Bavel, Bert;Tornero, Victoria
非目标筛选（NTS），包括用高分辨率质谱法进行的可疑筛选，已经显示出其在检测和识别新出现的污染物方面的可行性，这随后引发了接触缓解措施。国家技术支助系统在有效评价物质和产品安全销售条例、确定监测方案所用物质的优先次序和评估环境质量等方面具有很大的潜力。为实现这一目标，需要进一步发展NTS方法，包括：（一）协调一致的协议和质量要求，（二）有效数据管理、数据评价和数据共享的基础设施，以及（三）欧洲研究和监管界有足够的资源和经过适当培训的人员。以下讨论文件概述了实现这三项要求的建议。特别是，为了便利化合物的鉴定，建议应向科学界提供解释质谱的相关信息以及关于化合物使用和生产吨位的信息（通过开放式数据库）。出于许多目的，NTS应与基于效果的方法结合实施，以关注有毒化学品。
Non-target screening (NTS) including suspect screening with high resolution mass spectrometry has already shown its feasibility in detecting and identifying emerging contaminants, which subsequently triggered exposure mitigating measures. NTS has a large potential for tasks such as effective evaluation of regulations for safe marketing of substances and products, prioritization of substances for monitoring programmes and assessment of environmental quality. To achieve this, a further development of NTS methodology is required, including: (i) harmonized protocols and quality requirements, (ii) infrastructures for efficient data management, data evaluation and data sharing and (iii) sufficient resources and appropriately trained personnel in the research and regulatory communities in Europe. Recommendations for achieving these three requirements are outlined in the following discussion paper. In particular, in order to facilitate compound identification it is recommended that the relevant information for interpretation of mass spectra, as well as about the compounds usage and production tonnages, should be made accessible to the scientific community (via open-access databases). For many purposes, NTS should be implemented in combination with effect-based methods to focus on toxic chemicals.