Comparison of risk factors in patients with transient and prolonged eye and brain ischemic syndromes
Comparison of risk factors in patients with transient and prolonged eye and brain ischemic syndromes
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DOI：
10.1161/01.str.0000029827.93497.97
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发表时间：
2002-10-01
期刊：
影响因子：
8.3
通讯作者：
Dennis, MS
中科院分区：
文献类型：
--
作者：
Mead, GE;Lewis, SC;Dennis, MS
背景和目的：缺血性卒中、短暂性脑缺血发作（TIA）、视网膜动脉阻塞（RAO）和一过性黑蒙患者被认为具有相似的危险因素和潜在的血管疾病。然而，如果风险因素是不同的患者与眼睛相比，大脑的症状，并在那些症状持续24小时（延长），更集中的预防策略是可能的，在future. Methods-所有患者缺血性中风，脑TIA，RAO，和黑朦提出我们的医院从1994年至1999年进行了检查，中风医生。记录危险因素，患者进行颈动脉多普勒超声。结果，我们登记1491例缺血性中风，580例脑TIA，79例RAO，138例一过性黑蒙。无论是长期[缺血性卒中vs RAO：比值比（OR），3.6; 95%置信区间（CI），1.1 - 12]还是短暂性，脑房颤比眼事件更常见（脑性TIA与一过性黑蒙：OR，2.9; 95% CI，0.7 - 13），并且在长期事件中比短暂事件更常见，无论脑（卒中与脑TIA：OR，3.3; 95% CI，2.1至5.1）或眼睛（RAO与一过性黑蒙：OR，2.7; 95% CI，0.4至16）。严重的同侧颈动脉疾病是不常见的大脑比眼睛的事件，无论是长期的（缺血性中风与RAO：OR，0.6; 95%CI，0.3至1.0）或短暂的（脑短暂性脑缺血发作与黑蒙：OR，0.4; 95%CI，0.2至0.6）。结论这些数据表明，有短暂性和永久性的眼睛和大脑缺血综合征之间的发病差异。对这些机制的更好理解可能会导致更有效的中风预防。
Background and Purpose-Patients with ischemic stroke, cerebral transient ischemic attacks (TIAs), retinal artery occlusion (RAO), and amaurosis fugax are thought to have similar risk factors and underlying vascular disease. However, if risk factors are different in patients with eye compared with brain symptoms and in those whose symptoms last 24 hours (prolonged), more focused prevention strategies are possible in the future.Methods-All patients with ischemic stroke, cerebral TIA, RAO, and amaurosis fugax presenting to our hospital from 1994 to 1999 were examined by a stroke physician. Risk factors were documented, and patients underwent carotid Doppler ultrasound.Results-We registered 1491 patients with ischemic stroke, 580 with cerebral TIA, 79 with RAO, and 138 with amaurosis fugax. Atrial fibrillation was more common in brain than eye events, whether prolonged [ischemic stroke versus RAO: odds ratio (OR), 3.6; 95% confidence interval (CI), 1.1 to 12] or transient (cerebral TIA versus amaurosis fugax: OR, 2.9; 95% CI, 0.7 to 13), and more common in prolonged than transient events, whether brain (stroke versus cerebral TIA: OR, 3.3; 95% CI, 2.1 to 5.1) or eye (RAO versus amaurosis fugax: OR, 2.7; 95% CI, 0.4 to 16). Severe ipsilateral carotid disease was less common in brain than eye events, whether prolonged (ischemic stroke versus RAO: OR, 0.6; 95% CI, 0.3 to 1.0) or transient (cerebral TIA versus amaurosis fugax: OR, 0.4; 95% CI, 0.2 to 0.6).Conclusions-These data suggest that there are pathogenetic differences between transient and permanent eye and brain ischemic syndromes. Improved understanding of these mechanisms could lead to more effective stroke prevention.