Hippocampal dysplasia in rats exposed to cocaine in utero
Hippocampal dysplasia in rats exposed to cocaine in utero
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DOI：
10.1016/s0165-3806(99)00106-6
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发表时间：
1999-11-18
期刊：
影响因子：
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通讯作者：
Schwartzkroin, PA
中科院分区：
文献类型：
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作者：
Baraban, SC;Wenzel, HJ;Schwartzkroin, PA
产前可卡因暴露可导致神经行为障碍和中枢神经系统的结构改变。在本研究中，将可卡因注射到怀孕的大鼠体内，并在光镜下检查其后代的大脑。成年后，可卡因暴露的后代表现出微妙但一致的海马异常。尤其是金字塔层（特别是CA1区）被层压中频繁的间隙打断，在东方层和辐射层中发现异位锥体细胞。(C) 1999 Elsevier Science B.V.版权所有
Prenatal cocaine exposure can result in neurobehavioral disturbances and structural modifications of the central nervous system. In the present study, cocaine was injected into pregnant rats and the brains of their offspring were examined at the light microscopic level. As adults, cocaine-exposed offspring exhibited subtle, but consistent, hippocampal abnormalities. In particular, the stratum pyramidale (particularly the CA1 region) was interrupted by frequent gaps in lamination, and ectopic pyramidal cells were found in stratum oriens and radiatum. (C) 1999 Elsevier Science B.V. All rights reserved.