ARGYROPHILIC GRAINS - CHARACTERISTIC PATHOLOGY OF CEREBRAL-CORTEX IN CASES OF ADULT ONSET DEMENTIA WITHOUT ALZHEIMER CHANGES
ARGYROPHILIC GRAINS - CHARACTERISTIC PATHOLOGY OF CEREBRAL-CORTEX IN CASES OF ADULT ONSET DEMENTIA WITHOUT ALZHEIMER CHANGES
复制标题
DOI：
10.1016/0304-3940(87)90204-7
复制
发表时间：
1987-04-23
影响因子：
2.5
通讯作者：
BRAAK, E
中科院分区：
文献类型：
--
作者：
BRAAK, H;BRAAK, E
研究人员对 56 名成年痴呆症患者的大脑进行了检查，这些患者没有肉眼可见的病变。四十个大脑显示出阿尔茨海默病的特征性细胞骨架变化。八个大脑未能显示出大量的神经炎斑块、神经原纤维缠结和神经绒毛线，但这些大脑显示出松散地散布在整个神经绒毛中的异常且强烈嗜银的颗粒的存在。在 CA1 层和 Pre-β 层的锥体层中遇到了大量这些小的纺锤形颗粒。内嗅区。八个大脑同时显示出阿尔茨海默病型的嗜银颗粒和神经原纤维变化。神经纤维内嗜银颗粒的出现被认为是与成人痴呆相关的未知疾病的形态学基础。
Brains from 56 individuals suffering from adult onset dementia and devoid of macroscopically detectable infractions were examined. Forty brains showed the characteristic cytoskeleton changes of Alzheimer''s disease. Eight brains failed to reveal considerable numbers of neuritic plaques, neurofibrillary tangles, and neuropil threads, but these brains showed the presence of abnormal and intensely argyrophilic grains loosely scattered throughout the neuropil. Abundant numbers of these small spindle-shaped grains were encountered within the pyramidal layers of CA1 and layer Pre-.beta. of the entorhinal region. Eight brains showed both the argyrophilic grains and the neurofibrillary changes of the Alzheimer type. The appearance of argyrophilic grains within the neuropil is considered a morphological substrate of an unknown disease associated with adult onset dementia.