ACCELERATED NOREPINEPHRINE TURNOVER IN PERIPHERAL-TISSUES AFTER VENTROMEDIAL HYPOTHALAMIC-STIMULATION IN RATS
ACCELERATED NOREPINEPHRINE TURNOVER IN PERIPHERAL-TISSUES AFTER VENTROMEDIAL HYPOTHALAMIC-STIMULATION IN RATS
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DOI：
10.1016/0006-8993(89)90806-8
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发表时间：
1989-03-06
期刊：
影响因子：
2.9
通讯作者：
SHIMAZU, T
中科院分区：
文献类型：
--
作者：
SAITO, M;MINOKOSHI, Y;SHIMAZU, T
为探讨下丘脑腹内侧核（VMH）与交感神经系统之间的功能联系，观察了电刺激VMH、下丘脑外侧区（LH）和室旁核（PVN）对心、肝、胰、脾、颌下腺和肩胛间棕色脂肪组织去甲肾上腺素（NE）代谢的影响。刺激VMH引起NE周转率在所有器官检查的3-8倍增加，而刺激LH或PVN没有明显的影响。交感神经节阻滞后，VMH刺激的效果被取消六烃季铵。肾上腺皮质激素的周转不仅通过刺激VMH而且通过刺激LH来加速。结论VMH与外周组织的交感易化密切相关。
To obtain evidence for a functional connection between the ventromedial hypothalamic nucleus (VMH) and the sympathetic nervous system, effects of electrical stimulation of the VMH, the lateral hypothalamic area (LH) and the paraventricular hypothalamic nucleus (PVN) on norepinephrine (NE) turnover in the heart, liver, pancreas, spleen, submandibular gland and the interscapular brown adipose tissue were examined in anesthesized rats. Stimulation of the VMH elicited a 3-8-fold increase in the rate of NE turnover in all organs examined, whereas stimulation of the LH or the PVN had no appreciable effects. The effect of VMH stimulation was abolished after sympathetic ganglionic blockade with hexamethonium. Epinephrine turnover in the adrenal gland was accelerated by stimulation of not only the VMH but also the LH. It was concluded that the VMH is intimately associated with sympathetic facilitation in peripheral tissues.