Growth and development of “antigen‐free” grafts of foetal mouse intestine
Growth and development of “antigen‐free” grafts of foetal mouse intestine
复制标题
胎鼠肠道“无抗原”移植物的生长和发育
作者：
Anne A. Ferguson;D. Parrott
有间接证据表明，正常食物抗原的免疫刺激作用以两种方式影响小肠粘膜层。在哺乳和无菌啮齿动物中，不仅小肠粘膜中的淋巴细胞较少（Dubos，1966; CrabbC等人，1970），但隐窝细胞有丝分裂速率和上皮细胞损失速率低于成年、常规饲养和喂养的动物（Abrams、Bauer和Sprinz，1963;奥康纳，1966）。
THERE is indirect evidence that immune stimulation by normal food antigens affects the mucosal layer of the small intestine in two ways. In suckling and germ-free rodents, not only are there fewer lymphoid cells in the small-intestinal mucosa (Dubos, 1966; CrabbC et al., 1970), but crypt-cell mitotic rates and the rate of epithelial cell loss are slower than in adult, conventionally reared and fed animals (Abrams, Bauer and Sprinz, 1963; O’Connor, 1966).