Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors.
Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors.
复制标题
用于双模态超声/磁共振成像和协同化疗/热疗对抗深部肿瘤的介孔复合纳米粒子
DOI：
10.2147/ijn.s144058
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发表时间：
2017
影响因子：
8
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Zhang N;Wang R;Hao J;Yang Y;Zou H;Wang Z
高强度聚焦超声(HIFU)是治疗实体肿瘤的一种很有前途的非侵入性治疗方法，具有潜在的临床应用价值。然而，HIFU治疗肝细胞癌等大而深的肿瘤的临床应用受到成像指导不理想、治疗时间长以及高功率照射对肿瘤周围正常组织损伤等问题的严重限制。在本研究中，我们开发了阿霉素/全氟己烷包裹的中空介孔普鲁士蓝纳米粒(HMPBS-DOX/PFH)作为治疗药物，它可以有效地指导HIFU治疗，并通过降低空化阈值来提高其联合化疗的疗效。我们研究了该试剂在体外和体内对超声和磁共振成像的影响。此外，由于PFH的相变性能，我们展示了对肝癌的高效HIFU治疗效果，以及受控的药物释放。因此，我们得出结论，HMPB-DOX/PFH是一种安全有效的纳米平台，有望在临床环境下用于肿瘤治疗。
High-intensity focused ultrasound (HIFU) is a promising and noninvasive treatment for solid tumors, which has been explored for potential clinical applications. However, the clinical applications of HIFU for large and deep tumors such as hepatocellular carcinoma (HCC) are severely limited by unsatisfactory imaging guidance, long therapeutic times, and damage to normal tissue around the tumor due to the high power applied. In this study, we developed doxorubicin/perfluorohexane-encapsulated hollow mesoporous Prussian blue nanoparticles (HMPBs-DOX/PFH) as theranostic agents, which can effectively guide HIFU therapy and enhance its therapeutic effects in combination with chemotherapy, by decreasing the cavitation threshold. We investigated the effects of this agent on ultrasound and magnetic resonance imaging in vitro and in vivo. In addition, we showed a highly efficient HIFU therapeutic effect against HCC tumors, as well as controlled drug release, owing to the phase-transitional performance of the PFH. We therefore conclude that HMPB-DOX/PFH is a safe and efficient nanoplatform, which holds significant promise for cancer theranostics against deep tumors in clinical settings.