Reduced left-lateralized pattern of event-related EEG oscillations in infants at familial risk for language and learning impairment
Reduced left-lateralized pattern of event-related EEG oscillations in infants at familial risk for language and learning impairment
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DOI：
10.1016/j.nicl.2019.101778
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发表时间：
2019-01-01
影响因子：
4.2
通讯作者：
Benasich, April A.
中科院分区：
文献类型：
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作者：
Cantiani, Chiara;Ortiz-Mantilla, Silvia;Benasich, April A.
在几十毫秒内快速辨别连续听觉刺激的能力对言语和语言的发展至关重要，特别是在生命的第一年。这种技能被称为快速听觉处理(RAP)，在有语言和学习障碍(LLI)家族风险的婴儿中会发生变化，是未来语言结果的有力预测因素。在本研究中，我们调查了一组有LLI风险的意大利6个月大婴儿(FH+，n=24)的RAP的神经底物，即潜在的神经振荡模式，并与没有LLI家族史的对照婴儿(FH-，n=32)进行了比较。在非言语双重古怪范式中，通过高密度脑电记录大脑对基波频率和持续时间快速变化的反应。在FH+和FH-组中，事件相关电位发生器的来源均定位于左右听区。时频分析显示，在不同的人群中，theta(Theta)和Gamma(Gamma)的范围都不同。我们的结果显示，总体RAP刺激在FH婴儿中引发了更左侧的振荡模式，而FH+婴儿在theta和Gamma频段上都表现出更右侧的模式。有趣的是，FH+婴儿在异常辨别过程中表现出早期左侧伽马功率降低(从刺激开始后50ms开始)。扰动振荡动力学很可能构成解释RAP群体差异的一种候选神经机制。另外，震源位置上的群体差异表明，解剖差异可能是振荡活动差异的基础。关于早期振荡测量的预测价值，我们发现，源反应的幅度、振荡功率的大小和相位同步对20个月龄的表达词汇量有预测作用。这些结果进一步加深了我们对支持婴儿期典型和非典型快速听觉处理的神经机制之间的相互作用的理解。
The ability to rapidly discriminate successive auditory stimuli within tens-of-milliseconds is crucial for speech and language development, particularly in the first year of life. This skill, called Rapid Auditory Processing (RAP), is altered in infants at familial risk for language and learning impairment (LLI) and is a robust predictor of later language outcomes. In the present study, we investigate the neural substrates of RAP, i.e., the underlying neural oscillatory patterns, in a group of Italian 6-month-old infants at risk for LLI (FH + , n = 24), compared to control infants with no known family history of LLI (FH - , n = 32). Brain responses to rapid changes in fundamental frequency and duration were recorded via high-density electroencephalogram during a non-speech double oddball paradigm. Sources of event-related potential generators were localized to right and left auditory regions in both FH + and FH - groups. Time-frequency analyses showed variations in both theta (theta) and gamma (gamma) ranges across groups. Our results showed that overall RAP stimuli elicited a more left-lateralized pattern of oscillations in FH - infants, whereas FH + infants demonstrated a more right-lateralized pattern, in both the theta and gamma frequency bands. Interestingly, FH + infants showed reduced early left gamma power (starting at 50 ms after stimulus onset) during deviant discrimination. Perturbed oscillatory dynamics may well constitute a candidate neural mechanism to explain group differences in RAP. Additional group differences in source location suggest that anatomical variations may underlie differences in oscillatory activity. Regarding the predictive value of early oscillatory measures, we found that the amplitude of the source response and the magnitude of oscillatory power and phase synchrony were predictive of expressive vocabulary at 20 months of age. These results further our understanding of the interplay among neural mechanisms that support typical and atypical rapid auditory processing in infancy.