Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy - a review.
Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy - a review.
复制标题
DOI：
10.1186/s12891-016-1085-9
复制
发表时间：
2016-05-26
影响因子：
2.3
通讯作者：
Tenen A
中科院分区：
文献类型：
--
作者：
Freitag J;Bates D;Boyd R;Shah K;Barnard A;Huguenin L;Tenen A
骨关节炎是世界上疼痛和残疾的主要原因。随着人口老龄化，其发病率可能进一步增加。目前公认的医疗策略旨在控制症状，而不是改变疾病。包括关节置换在内的手术选择并非没有可能的严重并发症。由于对间充质干细胞在组织稳态和修复中的作用的理解不断加深，再生医学领域的兴趣日益浓厚，最近集中精力探索干细胞疗法在积极管理症状性骨关节炎中的潜力。令人鼓舞的是，临床前和临床试验的结果提供了有效性的初步证据，并表明了间充质干细胞疗法治疗膝关节骨关节炎的安全性。本文探讨了骨关节炎的发病机制，以及间充质干细胞如何在这种致残性疾病的未来管理策略中发挥作用。
Osteoarthritis is a leading cause of pain and disability across the world. With an aging population its prevalence is likely to further increase. Current accepted medical treatment strategies are aimed at symptom control rather than disease modification. Surgical options including joint replacement are not without possible significant complications. A growing interest in the area of regenerative medicine, led by an improved understanding of the role of mesenchymal stem cells in tissue homeostasis and repair, has seen recent focused efforts to explore the potential of stem cell therapies in the active management of symptomatic osteoarthritis. Encouragingly, results of pre-clinical and clinical trials have provided initial evidence of efficacy and indicated safety in the therapeutic use of mesenchymal stem cell therapies for the treatment of knee osteoarthritis. This paper explores the pathogenesis of osteoarthritis and how mesenchymal stem cells may play a role in future management strategies of this disabling condition.