Effects of long-term administration of estrogens on serum lipids of postmenopausal women.
Effects of long-term administration of estrogens on serum lipids of postmenopausal women.
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长期服用雌激素对绝经后妇女血脂的影响。
DOI：
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发表时间：
1960
影响因子：
158.5
通讯作者：
W. D. Cohen
中科院分区：
文献类型：
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作者：
R. W. Robinson;N. Higano;W. D. Cohen
现在公认的是，绝经后冠状动脉疾病的发病率增加。1,2对这种关联的一种可能的解释是，不仅在绝经后和过早阉割的妇女中，而且在患有冠状动脉疾病的妇女中，血脂水平都存在异常。因此，卵巢功能下降被认为是动脉粥样硬化的几个可能的病因之一。由于这似乎是绝经后状态雌激素替代治疗的合理基础，本研究的目的是确定达到最佳脂质变化所需的雌激素日剂量。
IT is now well recognized that the incidence of coronary-artery disease is increased in the post-menopausal state.1 , 2 A possible explanation for this association is the presence of abnormal serum lipid levels, not only in postmenopausal3 and prematurely castrated women4 but also in those with Coronary Artery disease.3 , 5 Thus, decreased ovarian function has been suggested as one of several possible etiologic factors in atherosclerosis. Since this appears to be a rational basis for estrogen replacement therapy in the postmenopausal state, the purpose of the present study was to determine the daily dosage of estrogen required to attain optimal lipid changes with . . .