Dissociation of task engagement and arousal effects in auditory cortex and midbrain.
Dissociation of task engagement and arousal effects in auditory cortex and midbrain.
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DOI：
10.7554/elife.60153
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发表时间：
2021-02-11
期刊：
影响因子：
7.7
通讯作者：
David SV
中科院分区：
文献类型：
--
作者：
Saderi D;Schwartz ZP;Heller CR;Pennington JR;David SV
一般性唤醒和参与特定任务都会影响感觉神经处理。为了隔离这些状态变量在听觉系统中的影响，我们记录了单个单元活动的初级听觉皮层（A1）和下丘（IC）的雪貂在音调检测任务，同时监测唤醒通过瞳孔大小的变化。我们使用了一个广义线性模型来评估任务参与和瞳孔大小对声音诱发活动的影响。在这两个领域，这两个变量影响独立的神经群体。在IC中，瞳孔大小效应更为突出，而在A1中，瞳孔和任务参与效应同样可能。任务参与与较大的瞳孔，因此，一些明显的影响任务参与实际上应归因于瞳孔大小的波动。这些结果表明，听觉处理的层次结构，其中广泛的唤醒增强中脑的活动，和特定的任务参与的影响变得更加突出的皮层。
Both generalized arousal and engagement in a specific task influence sensory neural processing. To isolate effects of these state variables in the auditory system, we recorded single-unit activity from primary auditory cortex (A1) and inferior colliculus (IC) of ferrets during a tone detection task, while monitoring arousal via changes in pupil size. We used a generalized linear model to assess the influence of task engagement and pupil size on sound-evoked activity. In both areas, these two variables affected independent neural populations. Pupil size effects were more prominent in IC, while pupil and task engagement effects were equally likely in A1. Task engagement was correlated with larger pupil; thus, some apparent effects of task engagement should in fact be attributed to fluctuations in pupil size. These results indicate a hierarchy of auditory processing, where generalized arousal enhances activity in midbrain, and effects specific to task engagement become more prominent in cortex.