Inflammation in ankylosing spondylitis:: a systematic description of the extent and frequency of acute spinal changes using magnetic resonance imaging
Inflammation in ankylosing spondylitis:: a systematic description of the extent and frequency of acute spinal changes using magnetic resonance imaging
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DOI：
10.1136/ard.2004.029298
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发表时间：
2005-05-01
影响因子：
27.4
通讯作者：
Braun, J
中科院分区：
文献类型：
--
作者：
Baraliakos, X;Landewé, R;Braun, J
背景资料：磁共振成像（MRI）越来越多地用于检测强直性脊柱炎（AS）患者脊柱的炎症。目的：通过MRI来区别检测AS患者脊柱三个节段的炎症存在和程度。方法：在38例活动性AS患者中，通过T-1加权，钆增强，自旋回波MRI（T-1/Gd-DTPA）和短tau反转恢复（STIR）序列。通过经验证的评分系统ASspiMRI-a对MRI进行量化。急性脊髓病变在整个脊柱和每个脊柱节段中检测到。一个椎体单位（VU）被定义为两个虚拟线之间的区域绘制通过中间的每个vertebralbody.Results：一个更大的数量的炎性脊髓病变被发现的STIR序列比GdDTPA：炎症存在于30.6%的VU评估的STIR，与26.8%的相同的VU评估的T-1/Gd-DTPA。使用两种技术，胸椎（TS）的炎症比颈椎（CS）或腰椎（LS）更常见。当使用STIR时，分别在10/38（26%）、28/38（74%）和9/38（24%）例患者中检测到CS、TS和LS的脊柱炎症。两种技术均以T7/8为最常见的VU（T1/Gd-DTPA为27.8%，STIR为34.5%）。结论：脊髓炎症是AS患者的常见表现，TS更常见。ASspiMRI-a评分系统可用于评估AS的急性脊柱变化。
Background: Magnetic resonance imaging (MRI) is increasingly used to detect inflammation in the spine of patients with ankylosing spondylitis ( AS).Objectives: To detect differentially the presence and extent of inflammation in the three spinal segments of patients with AS by MRI.Methods: In 38 patients with active AS, acute spinal lesions were assessed by T-1 weighted, gadolinium enhanced, spin echo MRI (T-1/Gd-DTPA) and short tau inversion recovery (STIR) sequences. MRI was quantified by the validated scoring system ASspiMRI-a. Acute spinal lesions were detected in the whole spine and in each spinal segment. One vertebral unit ( VU) was defined as the region between two virtual lines drawn through the middle of each vertebral body.Results: A greater number of inflammatory spinal lesions were found by the STIR sequence than by GdDTPA: inflammation was present in 30.6% of the VUs as assessed by STIR, compared with 26.8% of the same VUs assessed by T-1/Gd-DTPA. Inflammation was found more commonly in the thoracic spine ( TS) than in the cervical ( CS) or the lumbar spine (LS) with both techniques. When STIR was used, spinal inflammation in the CS, the TS, and LS was detected in 10/38 (26%), 28/38 (74%), and 9/38 (24%) patients, respectively. The VU T7/8 was found to be the VU most often affected by both techniques (27.8% by T-1/Gd-DTPA and 34.5% by STIR).Conclusions: Spinal inflammation is a common manifestation in patients with AS, and appears more frequently in the TS. The scoring system ASspiMRI-a can be used for evaluation of acute spinal changes in AS.