The effects of rate variation on ancestral inference in the coalescent.
The effects of rate variation on ancestral inference in the coalescent.
复制标题
速率变化对合并中祖先推理的影响。
DOI：
10.1093/genetics/156.3.1427
复制
发表时间：
2000
期刊：
影响因子：
3.3
通讯作者：
Tavaré,S
中科院分区：
文献类型：
--
作者：
Markovtsova,L;Marjoram,P;Tavaré,S
We describe a Markov chain Monte Carlo approach for assessing the role of site-to-site rate variation in the analysis of within-population samples of DNA sequences using the coalescent. Our framework is a Bayesian one. We discuss methods for assessing the goodness-of-fit of these models, as well as problems concerning the separate estimation of effective population size and mutation rate. Using a mitochondrial data set for illustration, we show that ancestral inference concerning coalescence times can be dramatically affected if rate variation is ignored.
