CA 19-9 Level in Patients With Type 2 Diabetes Mellitus and Its Relation to the Metabolic Control and Microvascular Complications
CA 19-9 Level in Patients With Type 2 Diabetes Mellitus and Its Relation to the Metabolic Control and Microvascular Complications
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DOI：
10.1097/maj.0b013e3181f0e2a0
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发表时间：
2011-01-01
影响因子：
3.1
通讯作者：
Cakir, Bekir
中科院分区：
文献类型：
--
作者：
Gul, Kamile;Nas, Sevinc;Cakir, Bekir
前言：本研究旨在比较2型糖尿病(DM)患者和健康对照组血清CA19-9水平。并探讨CA19-9水平与糖尿病患者代谢控制及微血管并发症的关系。方法：选择340例2型糖尿病患者和214例年龄、性别、体重指数匹配的健康对照组。对糖化血红蛋白(1c)、糖尿病病程和糖尿病微血管并发症进行综述。测定所有受试者血清CA19-9水平(正常范围0~35U/mL)。结果：糖尿病患者血清CA19-9水平中位数明显高于对照组[19.5U/mL(0~214.8 U/mL)和7.4U/mL(0.4~47.0U/mL)](P<；0.001)。糖尿病患者CA19-9水平升高的发生率为31.2%，且CA19-9水平与年龄、病程、糖化血红蛋白(1c)、并发症数呈正相关。在多元线性回归分析中，糖尿病病程、糖化血红蛋白(1c)和糖尿病肾病的影响仍在继续。本研究利用多元回归分析中各变量的回归系数，试图确定糖尿病患者CA19-9水平的新界值。第97个百分位数的临界值为57.14U/m L。结论：糖尿病患者CA19-9水平较高，提示有必要对血糖调节和并发症进行仔细的评估。在这些患者中定义一个新的临界值将防止不必要的实验室或成像程序。
Introduction: The aim of this study is to compare CA 19-9 levels in patients with type 2 diabetes mellitus (DM) and healthy control group. The relation of CA 19-9 levels to metabolic control and microvascular complications in patients with diabetes was also investigated. Methods: Three hundred forty patients with type 2 DM and age-, sex- and body mass index-matched 214 healthy controls group were included in the study. HbA(1c), duration of DM and microvascular complications of DM were reviewed. CA 19-9 levels (normal range, 0-35 U/mL) were measured in all participants. Results: Median CA 19-9 level was significantly higher in patients with diabetes compared with control group [19.5 U/mL (0-214.8 U/mL) versus 7.4 U/mL (0.4-47.0 U/mL)] (P < 0.001). Prevalence of high CA 19-9 levels in patients with diabetes was 31.2%, and CA 19-9 level was positively correlated with age, duration of diabetes, HbA(1c) and number of complications. Effects of duration of diabetes, HbA(1c) and diabetic nephropathy were still continuing in multiple linear regression analysis. Using regression coefficients of all variables in multiple regression analysis, this study tried to determine a new cutoff value for CA 19-9 level in patients with diabetes. The cutoff value at 97th percentile was 57.14 U/mL. Conclusions: High CA 19-9 value in patients with diabetes may indicate the need for a careful evaluation of blood glucose regulation and investigation of complications. Defining a new cutoff value in these patients would prevent unnecessary laboratory or imaging procedures.