Liposomes as drug carriers: a technological approach.
Liposomes as drug carriers: a technological approach.
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DOI：
10.1016/s1387-2656(01)07033-8
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发表时间：
2001-01-01
期刊：
影响因子：
--
通讯作者：
Brandl, M
中科院分区：
文献类型：
--
作者：
Brandl, M
在过去的30年里，脂质体研究人员主要通过小规模的实验室技术，使用或多或少明确的原料，创造了各种各样的脂质体药物载体。到目前为止，只有少数这些脂质体制剂已被批准用于人类临床。综述了用于评价合适脂质配方以及制备、大小、装载和灭菌脂质体的关键技术的重要文献调查。它还涉及脂质体药物载体的质量和货架稳定性方面。
Liposome researchers have created a hugh variety of liposomal drug carriers in the past thirty years mainly by small-scale laboratory techniques using more or less well defined raw materials. Only a few of these liposomal preparations have made their way to approved drugs for clinical use in humans so far. The review gives a critical literature survey over key technologies, which are used to evaluate an appropriate lipid formula and to prepare, size, load and sterilise liposomes. It also deals with quality and shelf stability aspects of liposomal drug carriers.