Controlling the rate of penetration of a therapeutic drug into the wall of an artery by means of a pressurized balloon

Controlling the rate of penetration of a therapeutic drug into the wall of an artery by means of a pressurized balloon
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通过加压气球控制治疗药物渗透到动脉壁的速率

DOI：
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Robert Kohler
Robert Kohler
中科院分区：
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文献类型：
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作者：
John R. Stark;J. Gorman;E. Sparrow;J. Abraham;Robert Kohler

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的 本文的重点是提出，建模，并描述了一种方法， 加速治疗药物向人体组织的输送速率。的 研究的手段是一个加压，渗透壁气球充满了 药物和载体流体的均匀混合物。流体混合物， 由压力驱动，穿过球囊壁的厚度， 激光钻孔可以控制孔的数量和展开， 高度的精确度。因此，气球的壁可以是 可视为均质多孔介质，横向流体流动可 通过多孔介质模型分析。当气球在亲密的 与组织床的表面接触，治疗流体连续流动， 当它穿过气囊壁并穿透组织时。流速 可以通过适当选择球囊渗透性来控制， 流动介质的粘度和球囊内部的压力。的 药物的递送浓度通过将本发明的 气球聚焦理论与先前开发的组织床模型， 包括扩散和平流过程。摩擦学相互作用 对具有动脉壁的加压球囊进行了实验研究， 评估动脉瘤的可能形成。
The focus of this paper is to propose, model, and characterize a means of accelerating the rate of delivery of therapeutic drugs to human tissues. The investigated means is a pressurized, permeable-walled balloon filled with a homogeneous mixture of the drug and the carrier fluid. The fluid mixture, driven by pressure, traverses the thickness of the balloon wall through laser-drilled pores. The number and deployment of the pores can be controlled to a high degree of precision. As a consequence, the wall of the balloon can be regarded as a homogeneous porous medium, and the traversing fluid flow can be analyzed by means of porous media models. When the balloon is in intimate contact with the surface of a tissue bed, the therapeutic fluid flows in series as it passes through the balloon wall and penetrates the tissue. The flow rate can be controlled by proper selection of the balloon permeability, the viscosity of the flowing medium, and the pressure internal to the balloon. The delivered concentration of the drug was predicted by coupling the present balloon-focused theory with a previously developed tissue-bed model that includes both diffusion and advection processes. The tribologic interaction of the pressurized balloon with an artery wall was investigated experimentally to assess the possible formation of aneurysms.