Human papillomavirus in head and neck squamous cell carcinoma: Are some head and neck cancers a sexually transmitted disease?
Human papillomavirus in head and neck squamous cell carcinoma: Are some head and neck cancers a sexually transmitted disease?
复制标题
DOI：
10.1097/00001622-199905000-00010
复制
发表时间：
1999-05-01
影响因子：
3.4
通讯作者：
Shah, Keerti V.
中科院分区：
文献类型：
--
作者：
Gillison, Maura L.;Koch, Wayne M.;Shah, Keerti V.
有大量的流行病学和病毒学证据表明，高危型人乳头瘤病毒（HPV）在人类上皮细胞中具有致瘤性，特别是在宫颈中，HPV感染是癌症发展所必需的。在许多病例系列中，已在一定比例的头颈部鳞状细胞癌（HNSCC）中检测到HPV DNA。肿瘤标本中病毒的存在本身并不意味着因果关系。然而，最近的研究支持HPV在HNSCC的一个子集中的病因作用，特别是来自Waldeyer扁桃体环的低分化肿瘤。流行病学研究表明，暴露于HPV会增加HNSCC的风险，HPV感染可能与酒精和烟草暴露在肿瘤促进中相互作用。分子研究表明，转录活性病毒仅限于肿瘤细胞。进一步阐明HPV在HNSCC发展中的作用非常重要，因为目前正在开发的用于宫颈癌的HPV治疗性疫苗也可能对HNSCC的管理有益。
There is abundant epidemiologic and virologic evidence that high-risk human papillomaviruses (HPVs) are tumorigenic in human epithelia, particularly in the cervix, where HPV infection is necessary for cancer development. HPV DNA has been detected in a proportion of head and neck squamous cell carcinomas (HNSCCs) in numerous case series. The mere presence of the virus in tumor specimens, by itself, does not imply a causal relationship. However, recent studies support an etiologic role for HPVs in a subset of HNSCC, particularly poorly differentiated tumors arising from Waldeyer’s tonsillar ring. Epidemiologic studies have shown that exposure to HPV increases the risk of HNSCC, and HPV infection may interact with alcohol and tobacco exposure in tumor promotion. Molecular studies indicate that transcriptionally active virus is confined to tumor cells. It will be important to clarify further the role that HPV has in HNSCC development, because HPV-based therapeutic vaccines which are currently being developed for cervical cancer may also be of benefit in the management of HNSCC.