Glucocorticoid receptor physiology
Glucocorticoid receptor physiology
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DOI：
10.1007/s11154-007-9059-8
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发表时间：
2007-12-01
影响因子：
8.2
通讯作者：
DeFranco, Donald B.
中科院分区：
文献类型：
--
作者：
Heitzer, Marjet D.;Wolf, Irene M.;DeFranco, Donald B.
糖皮质激素在细胞中的作用是由一种特殊的受体蛋白，糖皮质激素受体（GR）介导的。GR是配体诱导型转录因子超家族的成员，其控制多种生理功能，例如代谢、发育和生殖。未配体GR主要定位于细胞质内，但在激素结合后快速有效地易位至细胞核。本文将重点介绍GR的胞内信号通路，包括控制其胞内运输、激素结合和转录调控的机制。许多受体相互作用蛋白参与GR信号转导的不同步骤，每种蛋白都具有独特的机制来调节受体作用，并为操纵对糖皮质激素的细胞反应提供潜在的药物靶点。
Glucocorticoid action in cells is mediated by a specific receptor protein, the glucocorticoid receptor (GR). GR is a member of a superfamily of ligand-inducible transcription factors that control a variety of physiological functions; such as, metabolism, development, and reproduction. Unliganded GR is predominantly localized within the cytoplasm but rapidly and efficiently translocates to the nucleus following hormone binding. This review will focus on the intracellular signaling pathway utilized by the GR including the mechanisms that control its intracellular trafficking, hormone binding and transcriptional regulation. Many receptor-interacting proteins are involved in distinct steps in GR signal transduction, each with a unique mechanism to regulate receptor action and providing potential drug targets for the manipulation of cellular responses to glucocorticoids.