Comparative study of suture and cyanoacrylates in skin closure of rats
Comparative study of suture and cyanoacrylates in skin closure of rats
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DOI：
10.1590/s0102-86502007000400013
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发表时间：
2007-08-01
影响因子：
1.1
通讯作者：
Carreiro, Mário Castro
中科院分区：
文献类型：
--
作者：
Souza, Sandro Cilindro de;Oliveira, Washington Luiz de;Carreiro, Mário Castro
目的：比较氰基丙烯酸酯乙酯（ECA）和氰基丙烯酸酯辛酯（OCA）在大鼠皮肤创面缝合中的生物相容性。方法：24只雄性Wistar大鼠分别用ECA、OCA或缝线缝合3个切口。将大鼠分为4组，分别于术后第3天、第7天、第14天、第21天行活检。检查坏死、炎症、皮炎、感染、开裂、瘢痕肿大及费用；组织病理学评价为上皮化、深开口、异物反应、合成材料残留、纤维化、炎症、开裂、坏死。结果：组织粘接剂开裂程度最大，ECA成本最低，其他措施相似。在组织病理学方面，深开口在OCA中更常见，肉芽肿在ECA中最常见。从术后第7天开始，两种组织粘接剂产生的炎症比初始缝合少，而ECA和OCA引起的炎症反应相似。ECA与OCA和缝线在其他指标上无显著差异。结论：在本研究中，ECA耐受性良好，不会引起坏死、过敏反应或感染，与OCA和缝合相比，具有成本更低、并发症更少的优势。
Purpose: To compare the biocompatibility of ethyl-cyanoacrylate (ECA) and octylcyanoacrylate (OCA) wound closures to sutures in rat skin. Methods: Twenty-four male Wistar rats were subjected to three incisions which were closed using ECA, OCA or sutures. Rats were divided into four groups which received biopsies on the 3(th), 7(th), 14(th) or 21(st) postoperative days. Necrosis, inflammation, dermatitis, infection, dehiscence, cicatricial enlargement and costs were examined; the histopathology evaluated was epithelialization, deep openings, foreign substance reaction, residues of synthesis material, fibrosis, inflammation, dehiscence and necrosis. Results: The tissue adhesives presented the largest dehiscence levels, and ECA the lowest cost while the other measures were similar. Regarding histopathology, deep openings were more common with OCA and granulomas were most frequently obtained with ECA. The two tissue adhesives produces less inflammation than the inicial suture from post-operative day 7, while ECA and OCA cause similar inflammatory reactions. ECA did not differ significantly from OCA and sutures on other measures. Conclusion: ECA was well tolerated in this study and did not induce necrosis, allergic reactions or infections, presenting several advantages in relation to OCA and sutures, including lower costs and fewer complications.