Optical Coherence Tomography Angiography for Detecting Choroidal Neovascularization Secondary to Punctate Inner Choroidopathy
Optical Coherence Tomography Angiography for Detecting Choroidal Neovascularization Secondary to Punctate Inner Choroidopathy
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DOI：
10.3928/23258160-20161130-13
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发表时间：
2016-12-01
影响因子：
1
通讯作者：
Sonoda, Koh-hei
中科院分区：
文献类型：
--
作者：
Nakao, Shintaro;Kaizu, Yoshihiro;Sonoda, Koh-hei
点状内脉络膜病（PIC）是一种相对罕见的炎性多灶性脉络膜视网膜病变，主要发生在年轻的近视女性。中央凹下脉络膜新生血管（CNV）常导致视力迅速丧失。荧光素血管造影（FA）和吲哚菁绿血管造影（ICGA）仍然是CNV诊断的现有金标准。然而，这些方法是侵入性的和耗时的。近年来，光学相干断层血管造影（OCTA）作为FA/ICGA的辅助手段被越来越多地使用。在本报告中，一名38岁的女性PIC和特发性CNV表现为视力模糊，尽管视力为18/20。FA显示阳性染色和可能的渗漏，但没有提供CNV的明确证据。OCTA检测到外视网膜异常血流，对应于2型CNV，在玻璃体内抗血管内皮生长因子（VEGF）治疗后减少。此外，OCTA可以显示治疗后脉络膜毛细血管的重塑。OCTA可能有助于检测、随访和评估治疗PIC继发CNV的治疗策略。
Punctate inner choroidopathy (PIC) is a relatively uncommon inflammatory multifocal chorioretinopathy that predominantly affects young, myopic women. Subfoveal choroidal neovascularization (CNV) often leads to rapid loss of sight. Fluorescein angiography (FA) and indocyanine green angiography (ICGA) remain the existing gold standards for CNV diagnosis. However, these methods are invasive and time-consuming. Recently, optical coherence tomography angiography (OCTA) has been used more frequently as an adjunct to FA/ICGA. In this report, a 38-year-old woman with PIC and idiopathic CNV presented with blurred vision despite 18/20 visual acuity. FA revealed positive staining and possible leakage, but did not provide clear evidence of CNV. OCTA detected abnormal flow in the outer retina, corresponding to type 2 CNV, that decreased following intravitreal anti-vascular endothelial growth factor (VEGF) therapy. Furthermore, OCTA could show remodeling of the choroidal capillaries after the treatment. OCTA may be helpful in the detection, follow-up, and evaluation of therapeutic strategies to treat CNV secondary to PIC.