Serum microRNA-21 is a novel biomarker in patients with esophageal squamous cell carcinoma
Serum microRNA-21 is a novel biomarker in patients with esophageal squamous cell carcinoma
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DOI：
10.1002/jso.23064
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发表时间：
2012-08-01
影响因子：
2.5
通讯作者：
Baba, Hideo
中科院分区：
文献类型：
--
作者：
Kurashige, Junji;Kamohara, Hidenobu;Baba, Hideo
近年来研究发现，microRNAs （miRNAs）可以稳定存在于血清中，并可能影响多种疾病的发病机制。然而，很少有报道表明mirna在食管鳞状细胞癌（ESCC）患者血清中的意义。因此，本研究的目的是阐明miRNA-21在ESCC患者血清中的地位，并揭示该分子作为生物标志物的实用性。方法采用实时RT-PCR检测71例ESCC患者和39例健康对照者血清中miRNA-21水平。我们还评估了手术和化疗期间miRNA-21水平的变化。结果ESCC患者血清miRNA-21浓度显著高于健康对照组(P？
Background It was recently revealed that microRNAs (miRNAs) can stably exist in serum and may affect the pathogenesis of several diseases. However, there are few reports that have demonstrated the significance of miRNAs in the serum of patients with esophageal squamous cell carcinoma (ESCC). Thus, the aims of this study were to clarify the status of miRNA-21 in serum of ESCC patients and to reveal the usefulness of this molecule as a biomarker. Methods We measured the miRNA-21 levels in serum samples from 71 ESCC patients and 39 healthy controls by using real-time RT-PCR. We also evaluated the changes in the miRNA-21 level during operation and chemotherapy. Results We found that serum concentration of miRNA-21 in ESCC patients was significantly higher than that in healthy controls (P?