Association of major depression and binge eating disorder with weight loss in a clinical setting
Association of major depression and binge eating disorder with weight loss in a clinical setting
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DOI：
10.1038/oby.2007.307
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发表时间：
2007-11-01
期刊：
影响因子：
6.9
通讯作者：
Ma, Yunsheng
中科院分区：
文献类型：
--
作者：
Pagoto, Sherry;Bodenlos, Jamie S.;Ma, Yunsheng
目的：临床和流行病学研究表明，肥胖与重度抑郁症（MDD）和暴食症（BED）有关。本研究比较了患有和不患有MDD和BED的患者的体重减轻，这些患者参加了以糖尿病预防计划为模型的医院减肥计划。研究方法和程序：在131名参加治疗的肥胖患者中，17%被诊断为仅患有MDD，13%被诊断为仅患有BED，17%被诊断为MDD和BED，53%的患者在治疗前的临床访谈中缺乏任何一种诊断。结果：治疗后，MDD患者的体重减轻仅为非抑郁症患者的63%。BED患者的体重减轻仅为非暴食者的55%。MDD对体重减轻的影响不能通过BED的存在来解释，反之亦然。只有27%的MDD和BED患者实现了临床显著的体重减轻，相比之下，67%的患者没有任何疾病。结果没有显着改变时，性别，年龄和糖尿病状态adjusted.Conclusion：MDD和BED是普遍存在于这个肥胖的临床人群中，每种疾病是独立的与更糟糕的结果。需要研究如何提高行为减肥计划对MDD和/或BED患者的疗效。
Objective: Obesity has been linked to both major depressive disorder (MDD) and binge eating disorder (BED) in clinical and epidemiological studies. The present study compared weight loss among patients with and without MDD and BED who participated in a hospital-based weight loss program modeled after the Diabetes Prevention Program.Research Methods and Procedures: Of 131 obese patients who enrolled in treatment, 17% were diagnosed with MDD only, 13% were diagnosed with BED only, 17% were diagnosed with both MDD and BED, and 53% lacked either diagnosis in a pretreatment clinical interview.Results: After treatment, patients with MDD only attained 63% of the weight loss that non-depressed patients attained. Patients with BED only attained 55% of the weight loss that non-binge eaters attained. The effect of MDD on weight loss was not accounted for by the presence of BED or vice versa. Only 27% of patients with both MDD and BED achieved clinically significant weight loss compared with 67% of patients who had neither disorder. Results were not significantly altered when gender, age, and diabetes status were adjusted.Conclusion: Both MDD and BED were prevalent among this obese clinical population, and each disorder was independently associated with worse outcomes. Research is needed to investigate how to increase the efficacy of behavioral weight loss programs for individuals with MDD and/or BED.